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Inflammation rather than Oxidative Stress is a Better Marker for Preeclampsia Vol 5(1)

Authors: Isaac Adediji, Ayodele Adelakun, ADEJUMO Esther , Tolulope Olaniyi, John , Paul , Victoria F. Adepoju

Publication Type: Journal article

Journal: Medical Journal Of Obstetrics And Gynecology

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Abstract

Background: Preeclampsia is a leading cause of maternal morbidity and mortality, characterised by hypertension and significant proteinuria with or without oedema occurring from late second trimester to third trimester of gestation in a previously normotensive, non-proteinuric woman. The condition is associated with an inflammatory response as well as oxidative stress. This study is therefore designed to assess the relationship between inflammatory and oxidative stress markers in severe preeclampsia, and to determine which is more associated with severe preeclampsia. Methods: We recruited 60 pregnant women in their third trimester into this study, grouped as 30 women with severe preeclampsia and 30 normotensive, non-proteinuric women. Serum high-sensitivity C-reactive protein and total antioxidant status as well as urinary protein levels were determined. Results: It was observed that the systolic blood pressure, diastolic blood pressure and serum HsCRP were significantly elevated in case subjects when compared with control subjects while the mean serum level of TAS was significantly reduced in case subjects when compared with controls. HsCRP also had a significant positive correlation with SBP, DBP and proteinuria while TAS had a significant negative correlation with HsCRP, SBP, DBP and proteinuria. Using the ROC curve, it was also observed that HsCRP has a greater area under curve than TAS. Conclusion: It could therefore be concluded that HsCRP is a better marker for severe preeclampsia than TAS and its measurement is useful in the management of preeclampsia.

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Isaac,O.A Ayodele,A.A ADEJUMO,E. Tolulope,M.O John,I. Paul,A. Victoria,F.A . (0000). Inflammation rather than Oxidative Stress is a Better Marker for Preeclampsia Vol 5(1), 5 (), 1-1.

Isaac,O.A Ayodele,A.A ADEJUMO,E. Tolulope,M.O John,I. Paul,A. Victoria,F.A . "Inflammation rather than Oxidative Stress is a Better Marker for Preeclampsia Vol 5(1)" 5, no (), (0000): 1-1.

Isaac,O.A and Ayodele,A.A and ADEJUMO,E. and Tolulope,M.O and John,I. and Paul,A. and Victoria,F.A and . (0000). Inflammation rather than Oxidative Stress is a Better Marker for Preeclampsia Vol 5(1), 5 (), pp1-1.

IsaacOA, AyodeleAA, ADEJUMOE, TolulopeMO, JohnI, PaulA, VictoriaFA, . Inflammation rather than Oxidative Stress is a Better Marker for Preeclampsia Vol 5(1). 0000, 5 ():1-1.

Isaac,O. Adediji, Ayodele,A. Adelakun, ADEJUMO,Esther , Tolulope,M. Olaniyi, John,Imaralu , Paul,Adepoju , and Victoria,F. Adepoju . "Inflammation rather than Oxidative Stress is a Better Marker for Preeclampsia Vol 5(1)", 5 . (0000) : 1-1.

I.O. Adediji A.A. Adelakun A.Esther T.M. Olaniyi J.Imaralu P.Adepoju & V.F. Adepoju , "Inflammation rather than Oxidative Stress is a Better Marker for Preeclampsia Vol 5(1)" vol.5, no., pp. 1-1, 0000.

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