Babcock University Research Portal

Magnesium upregulates insulin receptor and glucose transporter-4 in streptozotocin-nicotinamide-induced type-2 diabetic rats

Authors: Morakinyo O, Samuel , & ADEKUNBI Daniel

Publication Type: Journal article

Journal: Endocrine Regulations

ISSN Number:

Downloads

Views

Abstract

Objective. We investigated the eff ects of magnesium supplementation on glucose tolerance,
insulin sensitivity, oxidative stress as well as the concentration of insulin receptor and glucose
transporter-4 in streptozotocin-nicotinamide induced type-2 diabetic (T2D) rats.
Methods. Rats were divided into four groups designated as: 1) control (CTR); 2) diabetic untreated
(DU); 3) diabetic treated with 1 mg of Mg/kg diet (Mg1-D); and 4) diabetic treated with 2 mg
of Mg/kg diet (Mg2-D). T2D was induced with a single intraperitoneal (i.p.) injection of freshly
prepared streptozotocin (55 mg/kg) aft er an initial i.p. injection of nicotinamide (120 mg/kg). Glucose
tolerance, insulin sensitivity, lipid profi le, malondialdehyde (MAD) and glutathione content,
insulin receptors (INSR) and glucose transporter-4 (GLUT4), fasting insulin and glucose levels
were measured, and insulin resistance index was calculated using the homeostatic model assessment
of insulin resistance (HOMA-IR).
Results. Magnesium supplementation improved glucose tolerance and lowered blood glucose
levels almost to the normal range. We also recorded a noticeable increase in insulin sensitivity
in Mg-D groups when compared with DU rats. Lipid perturbations associated T2D were signifi
cantly attenuated by magnesium supplementation. Fasting glucose level was comparable to
control values in the Mg-D groups while the HOMA-IR index was signifi cantly lower compared
with the DU rats. Magnesium reduced MDA but increased glutathione concentrations compared
with DU group. Moreover, INSR and GLUT4 levels were elevated following magnesium supplementation
in T2D rats.
Conclusion. Th ese fi ndings demonstrate that magnesium may mediate eff ective metabolic control
by stimulating the antioxidant defense, and increased levels of INSR and GLUT4 in diabetic rats.

Access to Documents

External Link
Download
Digital Object Identifier

Keywords

Morakinyo,A.O Samuel,T. ADEKUNBI,D. . (0000). Magnesium upregulates insulin receptor and glucose transporter-4 in streptozotocin-nicotinamide-induced type-2 diabetic rats, 52 (), 6-6.

Morakinyo,A.O Samuel,T. ADEKUNBI,D. . "Magnesium upregulates insulin receptor and glucose transporter-4 in streptozotocin-nicotinamide-induced type-2 diabetic rats" 52, no (), (0000): 6-6.

Morakinyo,A.O and Samuel,T. and ADEKUNBI,D. and . (0000). Magnesium upregulates insulin receptor and glucose transporter-4 in streptozotocin-nicotinamide-induced type-2 diabetic rats, 52 (), pp6-6.

MorakinyoAO, SamuelT, ADEKUNBID, . Magnesium upregulates insulin receptor and glucose transporter-4 in streptozotocin-nicotinamide-induced type-2 diabetic rats. 0000, 52 ():6-6.

Morakinyo,Ayodele O, Samuel,Titilayo , and ADEKUNBI,Daniel . "Magnesium upregulates insulin receptor and glucose transporter-4 in streptozotocin-nicotinamide-induced type-2 diabetic rats", 52 . (0000) : 6-6.

M.Ayodele O S.Titilayo & A.Daniel , "Magnesium upregulates insulin receptor and glucose transporter-4 in streptozotocin-nicotinamide-induced type-2 diabetic rats" vol.52, no., pp. 6-6, 0000.

Access to Documents

Keywords

About Us

Admissions

Contact Us

Policies

ALUMNI

STUDENT POPULATION