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Prevention of Mother-to-Child Transmission of Hepatitis B virus

Authors: OLALEYE Atinuke , Olabisi Loto, Akinyemi Olaleye, Oliver C Ezechi

Publication Type: Journal article

Journal: Nigerian Journal Of Clinical And Biomedical Research

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Abstract

Perinatal transmission accounts for the majority of chronic Hepatitis B virus (HBV) infections in regions with high prevalence (i.e. >7%). Nigeria is a hyper-endemic region for HBV infection; therefore prevention of mother-to-child transmission (PMTCT) is essential. Maternal screening and neonatal immunoprophylaxis (active and passive) have greatly reduced vertical transmission in countries where such programmes have been established. Antenatal immunoglobulin and antiviral therapy in the third trimester of pregnancy in high-risk women with chronic HBV infection may also decrease the risk of perinatal transmission. Mode of delivery and breastfeeding has not been proven to significantly increase the risk of vertical transmission. A comprehensive discussion of the risks and benefits of therapy with the patient is necessary, in addition to the involvement of the hepatologist and paediatrician for follow-up. Prophylaxis however remains the best method of prevention of perinatal transmission.Perinatal transmission accounts for the majority of chronic Hepatitis B virus (HBV) infections in regions with high prevalence (i.e. >7%). Nigeria is a hyper-endemic region for HBV infection; therefore prevention of mother-to-child transmission (PMTCT) is essential. Maternal screening and neonatal immunoprophylaxis (active and passive) have greatly reduced vertical transmission in countries where such programmes have been established. Antenatal immunoglobulin and antiviral therapy in the third trimester of pregnancy in high-risk women with chronic HBV infection may also decrease the risk of perinatal transmission. Mode of delivery and breastfeeding has not been proven to significantly increase the risk of vertical transmission. A comprehensive discussion of the risks and benefits of therapy with the patient is necessary, in addition to the involvement of the hepatologist and paediatrician for follow-up. Prophylaxis however remains the best method of prevention of perinatal transmission.

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OLALEYE,A. Olabisi,M.L Akinyemi,O.O Oliver,C.E . (0000). Prevention of Mother-to-Child Transmission of Hepatitis B virus, 6 (), 28-28.

OLALEYE,A. Olabisi,M.L Akinyemi,O.O Oliver,C.E . "Prevention of Mother-to-Child Transmission of Hepatitis B virus" 6, no (), (0000): 28-28.

OLALEYE,A. and Olabisi,M.L and Akinyemi,O.O and Oliver,C.E and . (0000). Prevention of Mother-to-Child Transmission of Hepatitis B virus, 6 (), pp28-28.

OLALEYEA, OlabisiML, AkinyemiOO, OliverCE, . Prevention of Mother-to-Child Transmission of Hepatitis B virus. 0000, 6 ():28-28.

OLALEYE,Atinuke , Olabisi,Morebise Loto, Akinyemi,Oladapo Olaleye, and Oliver,C Ezechi . "Prevention of Mother-to-Child Transmission of Hepatitis B virus", 6 . (0000) : 28-28.

O.Atinuke O.Morebise Loto A.Oladapo Olaleye & O.C Ezechi , "Prevention of Mother-to-Child Transmission of Hepatitis B virus" vol.6, no., pp. 28-28, 0000.

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