Babcock University Research Portal

Hypothalamic effects of progesterone on regulation of the pulsatile and surge release of luteinising hormone in female rats

Authors: Wen , Xiaofeng , ADEKUNBI Daniel , Yali , Hui , Li , Qifeng , Yanping , Kevin T. O’byrne

Publication Type: Journal article

Journal: Scientific Reports

ISSN Number:

Downloads

Views

Abstract

Progesterone can block the oestradiol-induced GnRH/LH surge and inhibit LH pulse frequency. Recent studies reported that progesterone prevented premature LH surges during ovarian hyperstimulation in women. As the most potent stimulator of GnRH/LH release, kisspeptin is believed to mediate the positive and negative feedback effects of oestradiol in the hypothalamic anteroventral periventricular (AVPV) and arcuate (ARC) nuclei, while the region-specific role of progesterone receptors in these nuclei remains unknown. This study examined the hypothesis that progesterone inhibits LH surge and pulsatile secretion via its receptor in the ARC and/or AVPV nuclei. Adult female rats received a single injection of pregnant mare serum gonadotropin followed by progesterone or vehicle. Progesterone administration resulted in a significant prolongation of the oestrous cycle and blockade of LH surge. However, microinjection of the progesterone receptor antagonist, RU486, into the AVPV reversed the prolonged cycle length and rescued the progesterone blockade LH surge, while RU486 into the ARC shortened LH pulse interval in the progesterone treated rats. These results demonstrated that progesterone’s inhibitory effect on the GnRH/LH surge and pulsatile secretion is mediated by its receptor in the kisspeptin enriched hypothalamic AVPV and ARC respectively, which are essential for progesterone regulation of oestrous cyclicity in rats.

Access to Documents

External Link
Download
Digital Object Identifier

Keywords

Wen,H. Xiaofeng,L. ADEKUNBI,D. Yali,L. Hui,L. Li,W. Qifeng,L. Yanping,K. Kevin,T.O . (0000). Hypothalamic effects of progesterone on regulation of the pulsatile and surge release of luteinising hormone in female rats, 7 (), 1-1.

Wen,H. Xiaofeng,L. ADEKUNBI,D. Yali,L. Hui,L. Li,W. Qifeng,L. Yanping,K. Kevin,T.O . "Hypothalamic effects of progesterone on regulation of the pulsatile and surge release of luteinising hormone in female rats" 7, no (), (0000): 1-1.

Wen,H. and Xiaofeng,L. and ADEKUNBI,D. and Yali,L. and Hui,L. and Li,W. and Qifeng,L. and Yanping,K. and Kevin,T.O and . (0000). Hypothalamic effects of progesterone on regulation of the pulsatile and surge release of luteinising hormone in female rats, 7 (), pp1-1.

WenH, XiaofengL, ADEKUNBID, YaliL, HuiL, LiW, QifengL, YanpingK, KevinTO, . Hypothalamic effects of progesterone on regulation of the pulsatile and surge release of luteinising hormone in female rats. 0000, 7 ():1-1.

Wen,He , Xiaofeng,Li , ADEKUNBI,Daniel , Yali,Liu , Hui,Long , Li,Wang , Qifeng,Lyu , Yanping,Kuang , and Kevin,T. O’byrne . "Hypothalamic effects of progesterone on regulation of the pulsatile and surge release of luteinising hormone in female rats", 7 . (0000) : 1-1.

W.He X.Li A.Daniel Y.Liu H.Long L.Wang Q.Lyu Y.Kuang & K.T. O’byrne , "Hypothalamic effects of progesterone on regulation of the pulsatile and surge release of luteinising hormone in female rats" vol.7, no., pp. 1-1, 0000.

Access to Documents

Keywords

About Us

Admissions

Contact Us

Policies

ALUMNI

STUDENT POPULATION