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Kisspeptin in the medial amygdala and sexual behavior in male rats

Authors: Rebecca , Shengyun , ADEKUNBI Daniel , Minghan , Xiao Li, Kevin T O’byrne

Publication Type: Journal article

Journal: Neuroscience Letters

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Abstract

The medial amygdala (MeA) is crucial for sexual behavior; kisspeptin (Kiss1) also plays a role in sexual function. Kisspeptin receptor (Kiss1r) knockout mice display no sexual behavior. Recently Kiss1 and Kiss1r have been discovered in the posterodorsal subnucleus of the medial amygdala (MePD). We hypothesised that Kiss1 in the MePD may have an influence on male sexual behavior. To test this we bilaterally cannulated the MePD and infused kisspeptin-10 in male rats. This caused the rats to have multiple erections, an effect specific to Kiss1 receptor activation, because Kiss1r antagonism blocked the erectile response. When Kiss1 was infused into the lateral cerebroventricle, there were no observed erections. We also measured the plasma levels of LH when Kiss1 is infused into the MePD or lateral cerebroventricle; Kiss1 increased plasma LH to comparable levels when infused into both sites. We conclude that Kiss1 has a role in male sexual behavior, which is specific to the MePD.

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Rebecca,G. Shengyun,L. ADEKUNBI,D. Minghan,H. Xiao,F.L Kevin,T.O . (0000). Kisspeptin in the medial amygdala and sexual behavior in male rats, 627 (), 13-13.

Rebecca,G. Shengyun,L. ADEKUNBI,D. Minghan,H. Xiao,F.L Kevin,T.O . "Kisspeptin in the medial amygdala and sexual behavior in male rats" 627, no (), (0000): 13-13.

Rebecca,G. and Shengyun,L. and ADEKUNBI,D. and Minghan,H. and Xiao,F.L and Kevin,T.O and . (0000). Kisspeptin in the medial amygdala and sexual behavior in male rats, 627 (), pp13-13.

RebeccaG, ShengyunL, ADEKUNBID, MinghanH, XiaoFL, KevinTO, . Kisspeptin in the medial amygdala and sexual behavior in male rats. 0000, 627 ():13-13.

Rebecca,Gresham , Shengyun,Li , ADEKUNBI,Daniel , Minghan,Hu , Xiao,Feng Li, and Kevin,T O’byrne . "Kisspeptin in the medial amygdala and sexual behavior in male rats", 627 . (0000) : 13-13.

R.Gresham S.Li A.Daniel M.Hu X.Feng Li & K.T O’byrne , "Kisspeptin in the medial amygdala and sexual behavior in male rats" vol.627, no., pp. 13-13, 0000.

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