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Comparative anti-inflammatory activities of jatropha curcas, ocimum gratissimum and solanum scabrum leaves

Authors: SHOKUNBI Olutayo

Publication Type: Journal article

Journal: Journal Of Natural Product And Plant Resources

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Abstract

The methanolic extracts of the leaves of Jatropha curcas Linn. (Euphorbiaceae), Ocimum gratissimum Linn.
(Lamiaceae) and Solanum scabrum Mill. (Solanaceae) were investigated for possible anti-inflammatory activities.
The plant extract, suspended in 0.5?rboxymethyl cellulose (CMC) was orally administered to formaldehydeinduced
arthritic mice at a dose of 200mg/kg body weight for seven days. Control mice and standard mice, which
were also injected with formaldehyde, were administered 0.5% CMC and 20mg/kg indomethacin respectively for
seven days. Inflammation in the mice was assayed by monitoring paw oedema and by measuring the concentrations
of serum alanine aminotransferase (ALT) as well as serum aspartate aminotransferase (AST). Paw oedema was
substantially decreased by the oral administration of the methanolic extracts of J. curcas. O. gratissimum and S.
scabrum also decreased the paw oedema but to a lesser extent. Both serum ALT and AST were substantially
decreased by J. curcas and O. gratissimum but there was greater reduction of ALT than of AST by both plants
extracts. S. scabrum also caused a significant decrease in serum ALT concentration but the serum AST value was
only slightly decreased by this plant. These results strongly suggest the presence of strong anti-inflammatory
activities in the methanolic extracts of J. curcas and O. gratissimum leaves while S. scabrum probably possesses a
moderate anti-inflammatory activity.

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SHOKUNBI,O. . (2013). Comparative anti-inflammatory activities of jatropha curcas, ocimum gratissimum and solanum scabrum leaves, 3 (), 59-59.

SHOKUNBI,O. . "Comparative anti-inflammatory activities of jatropha curcas, ocimum gratissimum and solanum scabrum leaves" 3, no (), (2013): 59-59.

SHOKUNBI,O. and . (2013). Comparative anti-inflammatory activities of jatropha curcas, ocimum gratissimum and solanum scabrum leaves, 3 (), pp59-59.

SHOKUNBIO, . Comparative anti-inflammatory activities of jatropha curcas, ocimum gratissimum and solanum scabrum leaves. 2013, 3 ():59-59.

SHOKUNBI,Olutayo , . "Comparative anti-inflammatory activities of jatropha curcas, ocimum gratissimum and solanum scabrum leaves", 3 . (2013) : 59-59.

S.Olutayo , "Comparative anti-inflammatory activities of jatropha curcas, ocimum gratissimum and solanum scabrum leaves" vol.3, no., pp. 59-59, 2013.

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