God is holy because He is morally pure and free from defilement and sin. This raises the question as to why the book of Revelation would describe human beings and places with the same attribute of holiness which is used to describe God. Utilizing intertextual approach, this study attempted to clarify why holiness as an attribute would be assigned to God as well as human and non-human objects and places in the book of Revelation. Findings revealed that human beings, places, and objects derive their holiness from God, especially in the context of relationship with God. People are declared holy by God in the sense of being set apart for relationship with God. A place or an object becomes holy only in relation to being set apart for God and sacred use. People, places or objects can lose their holiness when they sever their connection and relationship with God. Through the sanctuary structure and its services as the concrete illustration of God's holiness, God mediated salvation to His people in the Old Testament times. The book of Revelation indicates that although God and Christ are holy, God's people, the saints are to go through varying experiences until He grants them salvation from persecution and martyrdom from His enemies; namely, Babylon, the beast from the sea, and the beast from the earth. Nevertheless, if the saints patiently endure to the end, God will avenge and vindicate them by saving them and punishing the powers that oppressed them.