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Caffeine and Cannabis Sativa Ingestion Affected Memory and Anxiety Levels in Juvenile Rat Models: A Potential Indication for Learning and Behavioural Aberrations in Users

Authors: Owolabi Joshua , ADEYEYE Joshua , & OLATUNJI SUNDAY YINKA

Publication Type: Journal article

Journal: Iosr Journal Of Nursing And Health Science (iosr-jnhs)

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Abstract

Cognition, memory and behavioural changes associated with the use of psychoactive substances are typically modelled in murine models. This study involved a modelling the use of caffeine and cannabis to provide information potential effects on learning and behavioural aberrations in users [humans]. The natures of memory retention and anxiety levels were observed in juvenile experimental animals after caffeine and cannabis treatment for 21 days. The investigation was conducted to observe the influence of caffeine and cannabis at various dosages on memory and anxiety which are key behavioural and cognition parameters and the regimen was particularly modelled to simulate human conditions of scenarios of these substances uses. Seventy two adult Wistar rats were divided into six groups. Group A was the control group; the Group B received 100mg/kg body weight of caffeine; Group C received 50mg/kg body weight of caffeine; Group D received 500mg/kg body weight of cannabis; Group E received 200mg/kg body weight of cannabis; Group F received 50mg/kg body weight of caffeine and 2000mg/kg body weight of cannabis combined. Animals were taken through the anxiety measurement tests using the elevated plus maze 24 hours after the last administration. The memory tests were conducted using the Barns Maze and this lasted 5 days. Memory and anxiety were generally influenced following different patterns across the treated groups relative to the control. Effects depended largely on substances and dosage.

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Owolabi,J. ADEYEYE,J. OLATUNJI,S. . (2017). Caffeine and Cannabis Sativa Ingestion Affected Memory and Anxiety Levels in Juvenile Rat Models: A Potential Indication for Learning and Behavioural Aberrations in Users, 6 (), 37-37.

Owolabi,J. ADEYEYE,J. OLATUNJI,S. . "Caffeine and Cannabis Sativa Ingestion Affected Memory and Anxiety Levels in Juvenile Rat Models: A Potential Indication for Learning and Behavioural Aberrations in Users" 6, no (), (2017): 37-37.

Owolabi,J. and ADEYEYE,J. and OLATUNJI,S. and . (2017). Caffeine and Cannabis Sativa Ingestion Affected Memory and Anxiety Levels in Juvenile Rat Models: A Potential Indication for Learning and Behavioural Aberrations in Users, 6 (), pp37-37.

OwolabiJ, ADEYEYEJ, OLATUNJIS, . Caffeine and Cannabis Sativa Ingestion Affected Memory and Anxiety Levels in Juvenile Rat Models: A Potential Indication for Learning and Behavioural Aberrations in Users. 2017, 6 ():37-37.

Owolabi,Joshua , ADEYEYE,Joshua , and OLATUNJI,SUNDAY YINKA . "Caffeine and Cannabis Sativa Ingestion Affected Memory and Anxiety Levels in Juvenile Rat Models: A Potential Indication for Learning and Behavioural Aberrations in Users", 6 . (2017) : 37-37.

O.Joshua A.Joshua & O.SUNDAY YINKA , "Caffeine and Cannabis Sativa Ingestion Affected Memory and Anxiety Levels in Juvenile Rat Models: A Potential Indication for Learning and Behavioural Aberrations in Users" vol.6, no., pp. 37-37, 2017.

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