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Piper guineense Effects on Testicular Histoarchitecture

Publication Type: Journal article

Journal: Journal Of Complementary And Alternative Medical Research

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Abstract

Piper guineense is used as spice and herb, particularly to enhance libido. P. guineense has effects on penile erection and copulatory behaviour which are controlled by androgens. This study was carried out to evaluate the effects of consumption of P. guineense leaves on testicular histoarchitecture. The effects of P. guineense ingestion, in form of pelleted formulation, on the histoarchitecture of the testis of adult male Wistar rats were studied. Thirty adult male Wistar rats were divided into six groups labelled A-F. Group A animals served as the control and they were fed ad libitum throughout the experiment. Dried and powdered P. guineense leaf was added to the feed of the rats in Groups B, C, D, E and F in graded proportions. Based on the well monitored and properly evaluated rate of feed consumption, the proportion of P. guineense in the feed for Groups B, C, D, E and F gave approximate daily dosage of 100, 200, 300, 400 and 500 mg/kg body weight respectively. The regimen design was to observe the possible influence of dosage variations. Animals in Groups B, C, D, E, and F were given the pelleted food formula for 28 days. Animals were sacrificed after treatments and the testes were excised and processed using the Eosin and Haematoxylin staining histological technique. Photomicrographs for histological analyses were taken with the aid of the digital Accuscope Photomicrographic Set. Results on the testicular histoarchitecture show that Piper guineense consumption affected testicular structural integrity and gametogenesis. Higher doses caused disruption in seminiferous tubules epithelium and general ultra structure. Though P. guineense had been reported to increase libido and frequency of male sexual activities, results from this investigation showed that its consumption might not enhance or improve male fertility.

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C.giwa,O. Owolabi,J. . (2016). Piper guineense Effects on Testicular Histoarchitecture, 12 (), 1-1.

C.giwa,O. Owolabi,J. . "Piper guineense Effects on Testicular Histoarchitecture" 12, no (), (2016): 1-1.

C.giwa,O. and Owolabi,J. and . (2016). Piper guineense Effects on Testicular Histoarchitecture, 12 (), pp1-1.

C.giwaO, OwolabiJ, . Piper guineense Effects on Testicular Histoarchitecture. 2016, 12 ():1-1.

C.giwa,O. , and Owolabi,Joshua . "Piper guineense Effects on Testicular Histoarchitecture", 12 . (2016) : 1-1.

C.O. & O.Joshua , "Piper guineense Effects on Testicular Histoarchitecture" vol.12, no., pp. 1-1, 2016.

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