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Investigating Potential Ameliorative Effects of Moringa Oleifera Leaf Ethanolic Extract on the Visual Cortex Retinopathy Wistar Rats Models

Authors: Owolabi Joshua , OLANREWAJU John , OLATUNJI SUNDAY YINKA , Faluyi Alexander

Publication Type: Journal article

Journal: Iosr Journal Of Environmental Science, Toxicology And Food Technology (iosr-jestft)

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Abstract

It is important to study possible relationships between retinopathy and visual cortex integrity. The human retina is a very delicate component of the human eye. Due to the retina's vital role in visual perception, damage to it can cause permanent blindness. Conditions such as retinopathy can compromise the integrity of its vascularity thereby preventing visual signals being sent to the brain hence leading to vision impairment or permanent loss of vision. The visual cortex, located in the occipital lobe of the brain, is the center for visual signals, sent from the retina through the optic nerve and the associating visual pathway components, translation into its original meaning. Lesions to the visual cortex automatically translate into vision integrity compromise. Retinopathic conditions basically occur due to oxidative reactions and Moringa oleifera leaves phytochemicals have been proven to contain potent anti-oxidants. Hence, this investigation studied the visual cortex structural and functional integrity in established condition of retinopathy using a 50mg/kg body weight dosage of sodium iodate (NaIO3). Four Groups of animals labeled A, B, C and D to serve as control [A], retinopathic group [B], treated group with lower dose of moringa extract [C] and treated group with higher dose of moringa extract [D] were studied respectively. Experiment lasted 11 days. Results showed retinopathy was induced, but without extensive damage to the visual cortex structural integrity. However, astrocytic reactions suggested mild assault to the visual cortex as well as elevated levels of the glutamate and GABA in the brain tissues. Moringa extract as used, however did not show significant evidence to ameliorate the observed changes associated with retinopathy.

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Owolabi,J. OLANREWAJU,J. OLATUNJI,S. Faluyi,A. . (2017). Investigating Potential Ameliorative Effects of Moringa Oleifera Leaf Ethanolic Extract on the Visual Cortex Retinopathy Wistar Rats Models, 11 (), 19-19.

Owolabi,J. OLANREWAJU,J. OLATUNJI,S. Faluyi,A. . "Investigating Potential Ameliorative Effects of Moringa Oleifera Leaf Ethanolic Extract on the Visual Cortex Retinopathy Wistar Rats Models" 11, no (), (2017): 19-19.

Owolabi,J. and OLANREWAJU,J. and OLATUNJI,S. and Faluyi,A. and . (2017). Investigating Potential Ameliorative Effects of Moringa Oleifera Leaf Ethanolic Extract on the Visual Cortex Retinopathy Wistar Rats Models, 11 (), pp19-19.

OwolabiJ, OLANREWAJUJ, OLATUNJIS, FaluyiA, . Investigating Potential Ameliorative Effects of Moringa Oleifera Leaf Ethanolic Extract on the Visual Cortex Retinopathy Wistar Rats Models. 2017, 11 ():19-19.

Owolabi,Joshua , OLANREWAJU,John , OLATUNJI,SUNDAY YINKA , and Faluyi,Alexander . "Investigating Potential Ameliorative Effects of Moringa Oleifera Leaf Ethanolic Extract on the Visual Cortex Retinopathy Wistar Rats Models", 11 . (2017) : 19-19.

O.Joshua O.John O.SUNDAY YINKA & F.Alexander , "Investigating Potential Ameliorative Effects of Moringa Oleifera Leaf Ethanolic Extract on the Visual Cortex Retinopathy Wistar Rats Models" vol.11, no., pp. 19-19, 2017.

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