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Modelling Rohypnol [Flunitrazepam] and Alcohol Abuse and Resultant Effects on Hippocampal Histoarchitecture and Biochemicals in Wistar Rats

Authors: Owolabi Joshua , OLATUNJI SUNDAY YINKA , OLANREWAJU John , Okeya Ogheneruno

Publication Type: Journal article

Journal: American Journal Of Laboratory Medicine

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Abstract

Rohypnol and alcohol abuse is often reported among young people. Rohypnol is often abused voluntarily to erase memory of indulgence. It is also used in perpetuating crime such as in rape cases when the perpetrator administers certain doses of rohypnol to make the victim lose the memory of such event. Interestingly, young people often abuse alcohol and rohypnol. While the former is often used as a social drug, the latter is combined in certain instances to erase or reduce the memory of such. A number of literatures exist on the effects of alcohol on heath, brain and mind; but not a good number of investigations have considered the effects of rohypnol on hippocampal structure as well as the nature of its effects when combined with alcohol. This particular investigation is aimed at modelling rohypnol and alcohol abuse and resultant effects on hippocampal histoarchitecture and biochemicals in Wistar rats. Forty eight [n=48] adult male Wistar rats were divided into six groups, A-F. Group A served as the control Group B received the low dose of flunitrazepam; Group C received the high dose of flunitrazepam; Group D received the low dose of alcohol; Group E received the high dose of alcohol; Group F received the low dose of flunitrazepam and alcohol. Experiment lasted 21 days and animals were sacrificed by cervical dislocation. Results showed that the two substances did not produce extensive structural disruption of the hippocampus. However, specific regions of the hippocampus showed morphological aberrations, resulting in mild heterogeneity. Also, the enzyme chemistry of the hippocampus cytochrome C oxidase and G6PDH enzymes was altered.

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Owolabi,J. OLATUNJI,S. OLANREWAJU,J. Okeya,O. . (2017). Modelling Rohypnol [Flunitrazepam] and Alcohol Abuse and Resultant Effects on Hippocampal Histoarchitecture and Biochemicals in Wistar Rats, 2 (), 112-112.

Owolabi,J. OLATUNJI,S. OLANREWAJU,J. Okeya,O. . "Modelling Rohypnol [Flunitrazepam] and Alcohol Abuse and Resultant Effects on Hippocampal Histoarchitecture and Biochemicals in Wistar Rats" 2, no (), (2017): 112-112.

Owolabi,J. and OLATUNJI,S. and OLANREWAJU,J. and Okeya,O. and . (2017). Modelling Rohypnol [Flunitrazepam] and Alcohol Abuse and Resultant Effects on Hippocampal Histoarchitecture and Biochemicals in Wistar Rats, 2 (), pp112-112.

OwolabiJ, OLATUNJIS, OLANREWAJUJ, OkeyaO, . Modelling Rohypnol [Flunitrazepam] and Alcohol Abuse and Resultant Effects on Hippocampal Histoarchitecture and Biochemicals in Wistar Rats. 2017, 2 ():112-112.

Owolabi,Joshua , OLATUNJI,SUNDAY YINKA , OLANREWAJU,John , and Okeya,Ogheneruno . "Modelling Rohypnol [Flunitrazepam] and Alcohol Abuse and Resultant Effects on Hippocampal Histoarchitecture and Biochemicals in Wistar Rats", 2 . (2017) : 112-112.

O.Joshua O.SUNDAY YINKA O.John & O.Ogheneruno , "Modelling Rohypnol [Flunitrazepam] and Alcohol Abuse and Resultant Effects on Hippocampal Histoarchitecture and Biochemicals in Wistar Rats" vol.2, no., pp. 112-112, 2017.

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