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Anti-Malaria Activity of Cocoa Powder in Mice.

Authors: KALE Oluwafemi

Publication Type: Journal article

Journal: African Journal Of Biochemistry Research

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Abstract

At present, malaria is one of the most important parasitic diseases in the world killing more than one
million people annually. It is an important public health problem because many of the drugs that are
being prescribed for the treatment of malaria have become ineffective to the disease. This study was
therefore carried out to determine the anti-malaria activity of cocoa powder through the use of mouse
model. Natural cocoa powder was used to compound mice feed and this was both pre-fed and post-fed
to mouse that had been infected with Plasmodium berghei. The results indicated that cocoa powder had
both therapeutic and prophylactic effects against P. berghei. The mean percentage plasmodial
reduction expressed in mice post-fed with cocoa and those treated with chloroquine were 60.82 ± 8.47%
and 60.09 ± 7.84% respectively. This is an indication that both agents exhibited plasmodial reduction
almost at equal frequency. Though, percentage plasmodium reduction was more in mice pre-fed with
cocoa than those post-fed with cocoa, but the difference was not significant (P > 0.05). The observation
of higher percentage of plasmodial reduction in mice pre-fed with cocoa suggested it may possess an
immune-booster effect which action is anti-malarial. There was a decline in weight of mice
demonstrating that cocoa might contain some weight trimming ingredients.

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KALE,O. . (2011). Anti-Malaria Activity of Cocoa Powder in Mice., 5 (), 328-328.

KALE,O. . "Anti-Malaria Activity of Cocoa Powder in Mice." 5, no (), (2011): 328-328.

KALE,O. and . (2011). Anti-Malaria Activity of Cocoa Powder in Mice., 5 (), pp328-328.

KALEO, . Anti-Malaria Activity of Cocoa Powder in Mice.. 2011, 5 ():328-328.

KALE,Oluwafemi , . "Anti-Malaria Activity of Cocoa Powder in Mice.", 5 . (2011) : 328-328.

K.Oluwafemi , "Anti-Malaria Activity of Cocoa Powder in Mice." vol.5, no., pp. 328-328, 2011.

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