Entrepreneurship education is a necessity in addressing the problem of unemployment of school leavers (secondary and tertiary education graduates) in Nigeria and the promotion of employment market for those who cannot employ themselves. Entrepreneurship education aims at preparing and equipping students of secondary and tertiary educational system with relevant theories, knowledge and practice of entrepreneurships. It is to prepare students to venture into job creation and nurturing of entrepreneurship successfully in emerging economies of Nigeria. The paper focuses on career guidance and entrepreneurship education, entrepreneurship skills needed in careers, examples of entrepreneurs required in Nigeria, how to identify entrepreneurship skills and theories supporting career choice development. The role of self- concept and self-esteem in career choice. The paper concludes with recommendations on the need to place emphasis on entrepreneurship education in order to save the Nigerian school leavers and graduates from idleness and save Nigerian economy from diving downward.