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SPONDIAS MOMBIN MODULATES GLUCOSE HANDLING MECHANISMS IN TYPE I DIABETIC WISTAR RATS

Authors: OGUNSOLA Oluseyi

Publication Type: Journal article

Journal: International Journal Of Advanced Research

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Abstract

A major challenge in diabetic disease is the systemic glucose handling mechanisms with little effort directed at it in the recent past. Spondias mombin is a flowering plant of the anacardiacae family that has been credited with anti-diabetic properties. This study evaluated the antidiabetic activity of S. mombin, its effects on glucose transporter 4 (Glut-4) and adiponectin receptors signalling in streptozotocin-induced diabetic rats. Adult male Wistar rats (120-160g) were randomly divided into 4 groups. Group 1 were normo-glycemic control rats given regular rat chow and water. Group 2 served as negative hyperglycaemic control. Group 3 (High dose) and Group 4 (low dose) served as treatment groups which were pre-treated with 750mg/kg and 50mg/kg of S. mombin respectively for 21 days. Oral glucose tolerance test (OGTT) and insulin tolerance test (ITT) were done. Glut-4 and adiponectin expression were measured from the supernatant of the gastrocnemius homogenate using ELISA assay. Results were analysed using ANOVA with p<0>

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OGUNSOLA,O. . (2018). SPONDIAS MOMBIN MODULATES GLUCOSE HANDLING MECHANISMS IN TYPE I DIABETIC WISTAR RATS, 6 (), 1334-1334.

OGUNSOLA,O. . "SPONDIAS MOMBIN MODULATES GLUCOSE HANDLING MECHANISMS IN TYPE I DIABETIC WISTAR RATS" 6, no (), (2018): 1334-1334.

OGUNSOLA,O. and . (2018). SPONDIAS MOMBIN MODULATES GLUCOSE HANDLING MECHANISMS IN TYPE I DIABETIC WISTAR RATS, 6 (), pp1334-1334.

OGUNSOLAO, . SPONDIAS MOMBIN MODULATES GLUCOSE HANDLING MECHANISMS IN TYPE I DIABETIC WISTAR RATS. 2018, 6 ():1334-1334.

OGUNSOLA,Oluseyi , . "SPONDIAS MOMBIN MODULATES GLUCOSE HANDLING MECHANISMS IN TYPE I DIABETIC WISTAR RATS", 6 . (2018) : 1334-1334.

O.Oluseyi , "SPONDIAS MOMBIN MODULATES GLUCOSE HANDLING MECHANISMS IN TYPE I DIABETIC WISTAR RATS" vol.6, no., pp. 1334-1334, 2018.

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