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In-vivo Antiplasmodial Activity of Fractions of the Aqueous and Ethanolic Extracts of Stem Bark of Vitex doniana on Plasmodium berghei-berghei Infected Mice

Authors: Umaru Ladi, Emmanuel Halilu, UYAIABASI Gabriel , Bashar , Rukayya B. Aliyu

Publication Type: Journal article

Journal: Nigerian Journal Of Pharmaceutical And Biomedical Research

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Abstract

Malaria, a parasitic infection is still a global concern as there is resistance to the current effective Artemisinin Combination Therapies (ACTs). This calls for the need to search for new, potent and affordable replacement. This study aims at evaluating the prophylactic and curative antimalarial activity of the n-Hexane and ethyl acetate fractions of the aqueous and the ethanoli stem bark extracts of Vitex doniana (sweet) in P. berghei-berghei infected mice. The LD50 was determined using the Lorke’s method and was found to be orally safe at >5000mg/kg. The prophylactic and curative in-vivo antiplasmodial activity was studied on the fractions using standard methods. The antimalarial activity demonstrated by fractions showed a dose dependent reduction in parasitaemia levels compared to the treated groups. The ethyl acetate fraction at the highest dose of 200mg/kg body weight showed a prophylactic significant reduction in parasitaemia (81.81 %) at p<0>

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Umaru,M.L Emmanuel,M.H UYAIABASI,G. Bashar,I. Rukayya,B.A . (2018). In-vivo Antiplasmodial Activity of Fractions of the Aqueous and Ethanolic Extracts of Stem Bark of Vitex doniana on Plasmodium berghei-berghei Infected Mice, 3 (), 287-287.

Umaru,M.L Emmanuel,M.H UYAIABASI,G. Bashar,I. Rukayya,B.A . "In-vivo Antiplasmodial Activity of Fractions of the Aqueous and Ethanolic Extracts of Stem Bark of Vitex doniana on Plasmodium berghei-berghei Infected Mice" 3, no (), (2018): 287-287.

Umaru,M.L and Emmanuel,M.H and UYAIABASI,G. and Bashar,I. and Rukayya,B.A and . (2018). In-vivo Antiplasmodial Activity of Fractions of the Aqueous and Ethanolic Extracts of Stem Bark of Vitex doniana on Plasmodium berghei-berghei Infected Mice, 3 (), pp287-287.

UmaruML, EmmanuelMH, UYAIABASIG, BasharI, RukayyaBA, . In-vivo Antiplasmodial Activity of Fractions of the Aqueous and Ethanolic Extracts of Stem Bark of Vitex doniana on Plasmodium berghei-berghei Infected Mice. 2018, 3 ():287-287.

Umaru,Millicent Ladi, Emmanuel,M. Halilu, UYAIABASI,Gabriel , Bashar,Idris , and Rukayya,B. Aliyu . "In-vivo Antiplasmodial Activity of Fractions of the Aqueous and Ethanolic Extracts of Stem Bark of Vitex doniana on Plasmodium berghei-berghei Infected Mice", 3 . (2018) : 287-287.

U.Millicent Ladi E.M. Halilu U.Gabriel B.Idris & R.B. Aliyu , "In-vivo Antiplasmodial Activity of Fractions of the Aqueous and Ethanolic Extracts of Stem Bark of Vitex doniana on Plasmodium berghei-berghei Infected Mice" vol.3, no., pp. 287-287, 2018.

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