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Nicotine Anti-nociception: Possible Role for Calcium ion.

Authors: AJIBOYE Kolawole

Publication Type: Journal article

Journal: World Journal Of Medical Sciences

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Abstract

The present study was designed to determine the degree of participation of calcium ions in the antinociception produced by systemic nicotine. Adult male Wistar rats (180-220 g) pretreated with saline (10 mL kg ) or calcium channel blockers, verapamil or nifedipine (0.05-0.20 mg kg each) were injected with 11 nicotine (1 mg kg ) 15 min later. The animals were subjected to the hot plate test after another 30 min. 1 Hot plate latencies (HPL) were measured before (base line) and at 15, 30, 45 and 60 min after nicotine injection. Nicotine produced antinociception for 15 to 45 min peaking 30 min after injection. Intraperitoneal (i.p) administration of graded doses of nifedipine and verpamil each antagonized in part, the antinociception produced by nicotine. Systemic administration of the vehicle (10 mL kg ) did not alter nicotine-induced 1 antinociception. The data suggest that the antinociceptive responses produced by nicotine are mediated at least in part via the calcium ions.

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AJIBOYE,K. . (2006). Nicotine Anti-nociception: Possible Role for Calcium ion., 1 (), 119-119.

AJIBOYE,K. . "Nicotine Anti-nociception: Possible Role for Calcium ion." 1, no (), (2006): 119-119.

AJIBOYE,K. and . (2006). Nicotine Anti-nociception: Possible Role for Calcium ion., 1 (), pp119-119.

AJIBOYEK, . Nicotine Anti-nociception: Possible Role for Calcium ion.. 2006, 1 ():119-119.

AJIBOYE,Kolawole , . "Nicotine Anti-nociception: Possible Role for Calcium ion.", 1 . (2006) : 119-119.

A.Kolawole , "Nicotine Anti-nociception: Possible Role for Calcium ion." vol.1, no., pp. 119-119, 2006.

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