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Vascular Modulatory Roles of the Sex Hormones and Thyroxine in Tadalafil-treated Wistar Rats.

Authors: AJIBOYE Kolawole

Publication Type: Journal article

Journal: Research Journal Of Pharmaceutical, Biological And Chemical Sciences

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Abstract

Glucose handling and metabolism is disturbed in acute kidney injury; L-arginine is a component of nitric oxide (NO) which aids the delivery of blood to tissues. This study focused on investigating the underlying effect that L-arginine would have on glucose handling and GLUT-4 expression in rats with acute kidney injury. Oral glucose tolerance test was used to assess the rat’s ability to regulate glucose metabolism, glucose utilization by the cells and how quickly glucose is cleared from the blood. Insulin tolerance test was used to assess insulin resistance and the sensitivity of target organs to insulin, as well as the rate of glucose clearance from the blood. Glucose transporter 4 expression was assessed via ELISA. Results showed that glucose clearance from the blood was more effective and rapid in the arginine-treated groups when compared to the control group. L-arginine induced rapid insulin-like action which was effective after thirty minutes of oral glucose loading in both groups treated with arginine but the effect was not long-lasting. Similar result was observed from the insulin tolerance test, again indicating an insulin-like action of arginine. L-arginine produced no marked difference in GLUT-4 expression across the various groups showing that the insulin-like activity observed may not be via the activation of GLUT-4 channels or exocytosis of GLUT-4 proteins to the plasma membranes of insulin target organs. This study showed that L-arginine exhibits a rapid but un-sustained insulin-like action in glucose metabolism by clearing glucose from the blood and this action is not via the activation of GLUT-4 channels on plasma membranes.

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AJIBOYE,K. . (2019). Vascular Modulatory Roles of the Sex Hormones and Thyroxine in Tadalafil-treated Wistar Rats., 10 (), 235-235.

AJIBOYE,K. . "Vascular Modulatory Roles of the Sex Hormones and Thyroxine in Tadalafil-treated Wistar Rats." 10, no (), (2019): 235-235.

AJIBOYE,K. and . (2019). Vascular Modulatory Roles of the Sex Hormones and Thyroxine in Tadalafil-treated Wistar Rats., 10 (), pp235-235.

AJIBOYEK, . Vascular Modulatory Roles of the Sex Hormones and Thyroxine in Tadalafil-treated Wistar Rats.. 2019, 10 ():235-235.

AJIBOYE,Kolawole , . "Vascular Modulatory Roles of the Sex Hormones and Thyroxine in Tadalafil-treated Wistar Rats.", 10 . (2019) : 235-235.

A.Kolawole , "Vascular Modulatory Roles of the Sex Hormones and Thyroxine in Tadalafil-treated Wistar Rats." vol.10, no., pp. 235-235, 2019.

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