Oral administration of L-Ariginine Ameliorate NSAID-induced Gastric Injury in Wistar Rats.
Authors:
AJIBOYE Kolawole
Publication Type: Journal article
Journal: Saudi Journal Of Medical And Pharmaceutical Sciences.
ISSN Number:
0
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Abstract
A major trend in ulcer management currently is the role of nitric oxide (NO) and its agonists such as L-Arginine in ameliorating gastric ulcers. The current study focuses on the possible effects of L-Arginine supplementation on indomethacin-induced gastric ulcerations in rats. Male Wistar albino rats weighing between 150-180g were used and divided thus: Group I (Control) – saline, 8ml/kg, Group II- L-Arginine 1g/kg B.W for 3 days, Group III- L-Arginine 1g/kg B.W for 7 days. The effect of L-arginine supplementation was on indomethacin-induced gastric ulcerations, ulcer dimensions and histological profile of the gastric mucosa was examined. The result showed that arginine supplementation possesses capabilities of reducing ulcer formation as evident by the lower ulcer scores of the supplemented groups when compared with the Control. The 3-day supplemented group had a significantly lower ulcer score (p<0>
