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8. Olufunmiao O Olajuyigbe, Morenike O. Adeoye-Isijola, Babasola A. Osopale & Roger M Coopoosamy, 2018. In vitro effects of magnesium-aluminum hydroxide (Maalox) on the antibacterial activity of ciprofloxacin against clinical bacterial isolates. 12(2): 623-633. DOI:

Authors: OLAJUYIGBE Olufunmiso

Publication Type: Journal article

Journal: Journal Of Pure And Applied Microbiology

ISSN Number:

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Abstract

To investigate the in vitro effects of interactions between ciprofloxacin (CP) and
magnesium-aluminium hydroxide (MA) combined against selected Gram-positive and Gramnegative
bacteria. The interaction between CP and MA was accessed by agar diffusion method.
Comparing the susceptibility of the isolates to CP alone with those of Ciprofloxacin-Magnesiumaluminum
hydroxide (CPMA) combined showed that there were significant antagonistic and
synergistic interactions in vitro. Antibacterial activities of ciprofloxacin were increased with
4.5-6.0 ?g/ml of the MA but were drastically decreased with concentrations lower and higher
than 4.5-6.0 ?g/ml while development of resistant colonies within these zones of inhibitions was
recorded. The susceptibility of the isolated resistant colonies was lesser than those obtained
from the original isolates. The combination of ciprofloxacin (CP) and magnesium-aluminum
hydroxide (Maalox) (MA) against bacterial isolates could result in development of resistant
colonies. The roles of aluminum and magnesium in resistance development at the molecular
level require further studies.

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OLAJUYIGBE,O. . (2018). 8. Olufunmiao O Olajuyigbe, Morenike O. Adeoye-Isijola, Babasola A. Osopale & Roger M Coopoosamy, 2018. In vitro effects of magnesium-aluminum hydroxide (Maalox) on the antibacterial activity of ciprofloxacin against clinical bacterial isolates. 12(2): 623-633. DOI:, 12 (), 623-623.

OLAJUYIGBE,O. . "8. Olufunmiao O Olajuyigbe, Morenike O. Adeoye-Isijola, Babasola A. Osopale & Roger M Coopoosamy, 2018. In vitro effects of magnesium-aluminum hydroxide (Maalox) on the antibacterial activity of ciprofloxacin against clinical bacterial isolates. 12(2): 623-633. DOI:" 12, no (), (2018): 623-623.

OLAJUYIGBE,O. and . (2018). 8. Olufunmiao O Olajuyigbe, Morenike O. Adeoye-Isijola, Babasola A. Osopale & Roger M Coopoosamy, 2018. In vitro effects of magnesium-aluminum hydroxide (Maalox) on the antibacterial activity of ciprofloxacin against clinical bacterial isolates. 12(2): 623-633. DOI:, 12 (), pp623-623.

OLAJUYIGBEO, . 8. Olufunmiao O Olajuyigbe, Morenike O. Adeoye-Isijola, Babasola A. Osopale & Roger M Coopoosamy, 2018. In vitro effects of magnesium-aluminum hydroxide (Maalox) on the antibacterial activity of ciprofloxacin against clinical bacterial isolates. 12(2): 623-633. DOI:. 2018, 12 ():623-623.

OLAJUYIGBE,Olufunmiso , . "8. Olufunmiao O Olajuyigbe, Morenike O. Adeoye-Isijola, Babasola A. Osopale & Roger M Coopoosamy, 2018. In vitro effects of magnesium-aluminum hydroxide (Maalox) on the antibacterial activity of ciprofloxacin against clinical bacterial isolates. 12(2): 623-633. DOI:", 12 . (2018) : 623-623.

O.Olufunmiso , "8. Olufunmiao O Olajuyigbe, Morenike O. Adeoye-Isijola, Babasola A. Osopale & Roger M Coopoosamy, 2018. In vitro effects of magnesium-aluminum hydroxide (Maalox) on the antibacterial activity of ciprofloxacin against clinical bacterial isolates. 12(2): 623-633. DOI:" vol.12, no., pp. 623-623, 2018.

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