Babcock University Research Portal

Effect of trimethoprim-sulfamethoxazole and azithromycin prophylaxis on antimicrobial resistance of feacal Escherichia coli isolated from HIV-infected and TB patients in Ekiti State. 1(6): Articles 1027-

Authors: OLAJUYIGBE Olufunmiso

Publication Type: Journal article

Journal: American Journal Of Clinical Microbiology And Antimicrobials

ISSN Number:

Downloads

Views

Abstract

Aim: To determine the effect of Trimethoprim-Sulfamethoxazole and Azithromycin Prophylaxis
on Antimicrobial Resistance of Faecal Escherichia coli isolated from HIV-Infected and TB Patients
in Ekiti, Nigeria.
Method: A total of 360 samples were collected of which 300 isolates of E. coli were obtained from the
stool samples of HIV/AIDS patients on treatment, HIV/AIDS patients not on treatment, HIV/TB
co-infected patients, TB patients on treatment, TB patients not on treatment and apparently healthy
individuals. The sample was cultured on Eosin-Methylene Blue (EMB) agar plate and incubated at
37°C overnight. Colony showing the greenish metallic sheen was Gram stained, single rod shaped
(Bacilli), motile, indole positive, Simmons citrate negative, yellow butt and yellow slant with gas
production on Triple Sugar Ion Agar (TSIA) were considered to be E. coli.
Result: A total of 141 (47%) males and 159 (53%) female patients were involved in the study. Based
on the age distribution, age group 30 to 39 (n=80) has highest percentage while age group 60 and
above (29) has the lowest participation among the age groups. E. coli isolated from HIV/TB coinfected
reveals 40 (80%) and 41 (82%) resistant to SXT and AZM respectively while 23 (46%) and
29 (58%) of E. coli isolated from HIV patients on treatment were susceptible to SXT and AZM.
Tuberculosis patients on anti-TB treatment had 42 (84%) and 40 (80%) of the isolates resistant to
SXT and AZM respectively while E. coli isolated from newly diagnosed HIV patients were 25 (50%)
and 12 (24%) of the E. coli were resistant to SXT and AZM. Similarly, 28 (56%) and 11 (22%) of the
isolated E. coli from newly diagnosed TB patients show resistance to SXT and AZM respectively.
Conclusion: Faecal E. coli, an indicator organism for enteric pathogens, rapidly develops resistance
to SXT and AZM which are clinically important antimicrobials after their initiation as prophylaxis.

Access to Documents

External Link
Download
Digital Object Identifier

Keywords

OLAJUYIGBE,O. . (2018). Effect of trimethoprim-sulfamethoxazole and azithromycin prophylaxis on antimicrobial resistance of feacal Escherichia coli isolated from HIV-infected and TB patients in Ekiti State. 1(6): Articles 1027-, 1 (), 1-1.

OLAJUYIGBE,O. . "Effect of trimethoprim-sulfamethoxazole and azithromycin prophylaxis on antimicrobial resistance of feacal Escherichia coli isolated from HIV-infected and TB patients in Ekiti State. 1(6): Articles 1027-" 1, no (), (2018): 1-1.

OLAJUYIGBE,O. and . (2018). Effect of trimethoprim-sulfamethoxazole and azithromycin prophylaxis on antimicrobial resistance of feacal Escherichia coli isolated from HIV-infected and TB patients in Ekiti State. 1(6): Articles 1027-, 1 (), pp1-1.

OLAJUYIGBEO, . Effect of trimethoprim-sulfamethoxazole and azithromycin prophylaxis on antimicrobial resistance of feacal Escherichia coli isolated from HIV-infected and TB patients in Ekiti State. 1(6): Articles 1027-. 2018, 1 ():1-1.

OLAJUYIGBE,Olufunmiso , . "Effect of trimethoprim-sulfamethoxazole and azithromycin prophylaxis on antimicrobial resistance of feacal Escherichia coli isolated from HIV-infected and TB patients in Ekiti State. 1(6): Articles 1027-", 1 . (2018) : 1-1.

O.Olufunmiso , "Effect of trimethoprim-sulfamethoxazole and azithromycin prophylaxis on antimicrobial resistance of feacal Escherichia coli isolated from HIV-infected and TB patients in Ekiti State. 1(6): Articles 1027-" vol.1, no., pp. 1-1, 2018.

Access to Documents

Keywords

About Us

Admissions

Contact Us

Policies

ALUMNI

STUDENT POPULATION