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Multidrug and vancomycin resistance among clinical isolates of Staphylococcus aureus from different teaching hospitals in Nigeria. African Health Sciences 17(3): 797-807.

Authors: OLAJUYIGBE Olufunmiso

Publication Type: Journal article

Journal: African Helath Sciences

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Abstract

Backgrounds: Staphylococcus aureus has emerged as a major public health concern because of the occurrence of multi-drug
resistant strains. This study aimed at investigating the multi-drug and vancomycin resistance profile of S. aureus from different
infection sites in some teaching hospitals in Nigeria.
Methods: Swabs were collected from different infection sites from out-patients in three teaching hospitals from October 2015
to May, 2016. The antibiotic-susceptibility test was carried out with selected antibiotics usually administered anti-microbials in
the treatment of infections in these hospitals. The prevalence of multi-drug and vancomycin resistance strains of S. aureus from
clinical samples was determined using disk diffusion and agar dilution methods respectively.
Results: The result showed (165)82.5% of the isolates were resistant to ?3 antibiotics tested. They were highly resistant to
ceftazidime 180(90%), cloxacillin 171(85.6%) and augmentin 167(83.3%), but susceptible to ofloxacin 150(75%), gentamicin
142(71.7%), erythromycin 122(61.1%), ceftriaxone 111(55.6%) and cefuroxime 103(51.7%). All the isolates from the HVS were
all multidrug resistant strains. While (56)90.16% were multidrug resistant (MDR) in urine samples, followed by (8)88.89% MDR
strains in sputum, (37)88.81% MDR strains in semen, (49)71.64% MDR strains in wounds and (6)60% MDR strains in ear
swabs samples. Although (147)73.5% of the isolates were vancomycin susceptible S. aureus (VSSA), (30)15% were vancomycin
intermediate resistant S. aureus (VISA) and (89)44.5% of the isolates were considered vancomycin resistant S. aureus (VRSA).
Conclusions: The high percentage of the VRSA could have resulted from compromising treatment options and inadequate antimicrobial
therapy. The implication, infections caused by VRSA would be difficult to treat with vancomycin and other effective
antibiotics of clinical importance. Ensuring proper monitoring of drug administration will, therefore, enhance the legitimate role
of vancomycin as an empiric choice for both prophylaxis against and treatment of staphylococcal infections.

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OLAJUYIGBE,O. . (2017). Multidrug and vancomycin resistance among clinical isolates of Staphylococcus aureus from different teaching hospitals in Nigeria. African Health Sciences 17(3): 797-807., 17 (), 797-797.

OLAJUYIGBE,O. . "Multidrug and vancomycin resistance among clinical isolates of Staphylococcus aureus from different teaching hospitals in Nigeria. African Health Sciences 17(3): 797-807." 17, no (), (2017): 797-797.

OLAJUYIGBE,O. and . (2017). Multidrug and vancomycin resistance among clinical isolates of Staphylococcus aureus from different teaching hospitals in Nigeria. African Health Sciences 17(3): 797-807., 17 (), pp797-797.

OLAJUYIGBEO, . Multidrug and vancomycin resistance among clinical isolates of Staphylococcus aureus from different teaching hospitals in Nigeria. African Health Sciences 17(3): 797-807.. 2017, 17 ():797-797.

OLAJUYIGBE,Olufunmiso , . "Multidrug and vancomycin resistance among clinical isolates of Staphylococcus aureus from different teaching hospitals in Nigeria. African Health Sciences 17(3): 797-807.", 17 . (2017) : 797-797.

O.Olufunmiso , "Multidrug and vancomycin resistance among clinical isolates of Staphylococcus aureus from different teaching hospitals in Nigeria. African Health Sciences 17(3): 797-807." vol.17, no., pp. 797-797, 2017.

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