Effects of Allium sativum and Allium cepa on some Immunological Cells in Rats.
Authors:
ENITAN Samson
Publication Type: Journal article
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Abstract
Extracts of some spices have been reported to play a contributory role in enhancing immune function. We
evaluated and compared the effect(s) of single and combined oral administration of fresh aqueous onion (Allium cepa) and
garlic (Allium sativum) extracts at different concentrations on some immunological determinants in rats. CD4 cells of the rats
were estimated using Partec flow cytometric technique, while total and differential white blood cell (WBC) counts were
estimated using the Sysmsex® automated haematology analyzing technique. Our findings revealed that, CD4 and total WBC
counts were significantly increased (P≤0.05) in a dose-dependent manner in both onion (250mg/Kg/d: 349±11cell/ul and
2.75±0.15X103cell/l; 500mg/Kg/d: 389±10cells/μl and 3.05±0.05 X103cell/l; 750mg/Kg/d: 600±11cell/μl and
3.25±0.05X103cells/l) and garlic (250mg/Kg/d: 410±10cell/ul and 2.85±0.15X103cell/l; 500mg/Kg/d: 494±32cells/μl and
3.30±0.10 X103cell/l; 750mg/Kg/d: 684±11cell/μl and 3.55±0.05X103cells/l) treated rats when compared to the zero control
(200±11cells/μl and 1.55±0.05X103cells/l, respectively). Extract of garlic at 750mg/Kg/d had significantly increased the
CD4 cells and total white cell count when compared to other concentrations (P≤0.05). However, no significant effect was
observed on these parameters when extracts were combined (250mg/Kg/d: 252±21cell/μl and 1.80±0.10X103cells/l;
500mg/Kg/d: 315±21cells/ul and 2.10±0.10X103cells/l; 750mg/Kg/d: 368±10cells/μl and 2.35±0.05X103cells/l,
respectively), the differential WBC count showed a significant increase in the proportion of cell types (lymphocytes,
neutophils and monocytes) (P≤0.05). The results from this study revealed the immune boosting capabilities of Allium cepa
and Allium sativum, but underscored their synergistic activities.