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Coartemether Induced Oxidative and Hepatic Damage in Plasmodium berghei Strain Anka Infected Mice.

Authors: OGUNWENMO Kayode , & FASESAN OLUWATOYIN

Publication Type: Journal article

Journal: Bulletin Environmental Contamination & Toxicology

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Abstract

This study investigated the effect of coartemether on antioxidant and hepatotoxic biomarkers in Plasmodium berghei infected mice. Erythrocyte, hepatic and renal superoxide dismutase (2.71 ± 0.51; 1.96 ± 0.87; 2.84 ± 0.22 Units/mg protein respectively) and catalase (4.10 ± 0.10; 8.25 ± 1.24; 6.28 ± 0.11 Units/mg protein respectively) activities were significantly (p < 0.05) elevated in “parasitized and treated” (PnT) animals. Renal glutathione level (19.02 ± 0.20 ?g/mL) was elevated in PnT animals. Glutathione S-transferase and malondialdehyde levels in hepatic (8.76 ± 0.49 ?mol/min/mg; 527.23 ± 24.56 mmol/dL) and renal (3.35 ± 0.30 ?mol/min/mg; 464.42 ± 59.13 mmol/dL) tissues were significantly high (p < 0.05) in coartemether-treated animals alone. Plasma aspartate transferase (9.45 ± 3.59 U/L) and alanine transferase (5.78 ± 2.36 U/L) were high in PnT animals. Therefore, data indicates that in the presence of P. berghei, coartemether could alter the antioxidant status and induce hepatotoxic damage in mice.

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OGUNWENMO,K. FASESAN,O. . (2012). Coartemether Induced Oxidative and Hepatic Damage in Plasmodium berghei Strain Anka Infected Mice., 88 (), 108-108.

OGUNWENMO,K. FASESAN,O. . "Coartemether Induced Oxidative and Hepatic Damage in Plasmodium berghei Strain Anka Infected Mice." 88, no (), (2012): 108-108.

OGUNWENMO,K. and FASESAN,O. and . (2012). Coartemether Induced Oxidative and Hepatic Damage in Plasmodium berghei Strain Anka Infected Mice., 88 (), pp108-108.

OGUNWENMOK, FASESANO, . Coartemether Induced Oxidative and Hepatic Damage in Plasmodium berghei Strain Anka Infected Mice.. 2012, 88 ():108-108.

OGUNWENMO,Kayode , and FASESAN,OLUWATOYIN . "Coartemether Induced Oxidative and Hepatic Damage in Plasmodium berghei Strain Anka Infected Mice.", 88 . (2012) : 108-108.

O.Kayode & F.OLUWATOYIN , "Coartemether Induced Oxidative and Hepatic Damage in Plasmodium berghei Strain Anka Infected Mice." vol.88, no., pp. 108-108, 2012.

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