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Anti-depressant Activities of Theobroma cacao Extract on Reserpine-induced Depression in Female Wistar Rats

Authors: Adetunji Opeyemi , Ayannuga Ayodeji, Lawal Adetayo, Ezekwem Adeboye, Adetunji Iyabode Toyin

Publication Type: Journal article

Journal: Journal Of Krishna Institute Of Medical Sciences University

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Abstract

Background: Depression is one of the most common types of neurological disorder, which is a marked pattern of disturbances in emotional behavior, memory and hedonic processing. Aim and Objectives: To investigate the role of ethanolic extract of Theobroma cacao seed on the prefrontal cortex of female Wistar rats following reserpine-induced depression. Material and Methods: Thirty-six (36) female Wistar rats were used for this study. They were divided into six (A - F) groups (n = 6). Group A- control, Group B - 0.2 mg/kg reserpine, Group C - 10 mg/kg fluoxetine, Group D - 500 mg/kg Theobroma cacao seed extract, Group E - 0.2 mg/kg reserpine + 500mg/kg Theobroma cacao seed extract, Group F - 0.2 mg/kg reserpine + 10mg/kg fluoxetine. Animals were euthanized via cervical dislocation after the last day of administration and the prefrontal cortex and hippocampus were excised and fixed in 10% formalin solution for routine histological processing while the part used for biochemical assay were homogenized in phosphate buffer before centrifugation. Results: Morphological alteration and reduced population of prefrontal cortex and hippocampus neurons, reduced protein synthesis, poor behavioral patterns, reduced neurotransmission and induction of oxidative stress in reserpine exposed animal. Conclusion: Theobroma cacao seed extract was able to mitigate these aberrations.

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Adetunji,O. Ayannuga,O.A Lawal,I.A Ezekwem,C.A Adetunji,I.T . (2020). Anti-depressant Activities of Theobroma cacao Extract on Reserpine-induced Depression in Female Wistar Rats, 9 (), 27-27.

Adetunji,O. Ayannuga,O.A Lawal,I.A Ezekwem,C.A Adetunji,I.T . "Anti-depressant Activities of Theobroma cacao Extract on Reserpine-induced Depression in Female Wistar Rats" 9, no (), (2020): 27-27.

Adetunji,O. and Ayannuga,O.A and Lawal,I.A and Ezekwem,C.A and Adetunji,I.T and . (2020). Anti-depressant Activities of Theobroma cacao Extract on Reserpine-induced Depression in Female Wistar Rats, 9 (), pp27-27.

AdetunjiO, AyannugaOA, LawalIA, EzekwemCA, AdetunjiIT, . Anti-depressant Activities of Theobroma cacao Extract on Reserpine-induced Depression in Female Wistar Rats. 2020, 9 ():27-27.

Adetunji,Opeyemi , Ayannuga,Olugbenga Ayodeji, Lawal,Ismail Adetayo, Ezekwem,Chukwuebuka Adeboye, and Adetunji,Iyabode Toyin . "Anti-depressant Activities of Theobroma cacao Extract on Reserpine-induced Depression in Female Wistar Rats", 9 . (2020) : 27-27.

A.Opeyemi A.Olugbenga Ayodeji L.Ismail Adetayo E.Chukwuebuka Adeboye & A.Iyabode Toyin , "Anti-depressant Activities of Theobroma cacao Extract on Reserpine-induced Depression in Female Wistar Rats" vol.9, no., pp. 27-27, 2020.

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