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Helicobacter Pylori and Precancerous Lesions of the Stomach in a Southwestern Nigerian Population

Authors: Jemilohun Abiodun , Ilesanmi , Banjoko V

Publication Type: Journal article

Journal: West Africa Journal Of Medicine

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Abstract

Background: Gastric cancer develops from chronic gastritis through distinct precancerous lesions which include atrophic gastritis (AG), intestinal metaplasia (IM) and dysplasia in a sequential manner, all of which are related to Helicobacter pylori (H. pylori) infection. We determined the prevalence of H. pylori infection and the gastric premalignant conditions in a Southwestern Nigerian population with chronic gastritis.

Materials and methods: A prospective cross-sectional study conducted on 252 adult patients with dyspepsia at a faith-based tertiary health facility in Nigeria. Gastroscopy was performed on all the participants and five gastric biopsies were taken from each of them. Standard histological examination for H. pylori, gastritis and the precancerous lesions was performed on the specimens. The biopsy sampling and histological examination were performed in line with the Updated Sydney System recommendations. We summarized data by Means ± Standard Deviation, frequencies and percentages. Associations between categorical variables were tested by means of Chi-square test or Fisher exact test as appropriate. The cutoff for statistical significance was P-value < 0>

Results: A total of 78 (31.0%) subjects tested positive by histology for H. pylori infection. Of all the gastric precancerous lesions, AG had the highest prevalence [54 (21.4%)], followed by dysplasia [6 (2.4%)] and IM [3 (1.2%)]. Regarding the severity of the precancerous lesions, 47 (87.0%) subjects had mild AG while 7 (13.0%) had moderate AG. All the subjects with IM and dysplasia had mild or low-grade lesions.

Conclusion: The prevalence rates of gastric precancerous lesions in our study population were low.

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Jemilohun,A. Ilesanmi,A. Banjoko,V. . (2020). Helicobacter Pylori and Precancerous Lesions of the Stomach in a Southwestern Nigerian Population, 37 (), 373-373.

Jemilohun,A. Ilesanmi,A. Banjoko,V. . "Helicobacter Pylori and Precancerous Lesions of the Stomach in a Southwestern Nigerian Population" 37, no (), (2020): 373-373.

Jemilohun,A. and Ilesanmi,A. and Banjoko,V. and . (2020). Helicobacter Pylori and Precancerous Lesions of the Stomach in a Southwestern Nigerian Population, 37 (), pp373-373.

JemilohunA, IlesanmiA, BanjokoV, . Helicobacter Pylori and Precancerous Lesions of the Stomach in a Southwestern Nigerian Population. 2020, 37 ():373-373.

Jemilohun,Abiodun , Ilesanmi,Ao , and Banjoko,V . "Helicobacter Pylori and Precancerous Lesions of the Stomach in a Southwestern Nigerian Population", 37 . (2020) : 373-373.

J.Abiodun I.Ao & B.V , "Helicobacter Pylori and Precancerous Lesions of the Stomach in a Southwestern Nigerian Population" vol.37, no., pp. 373-373, 2020.

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