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Functional Diarrhoea in a Nigerian Community: Prevalence, Risk Factors and Associated Quality of Life

Authors: Jemilohun Abiodun , ELIKWU Charles , Ranajit , Adegboyega Odebode, Jens Frisvad, Yinka M Somorin

Publication Type: Journal article

Journal: Journal Of Clinical And Diagnostic Research

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Abstract

Introduction: Diarrhoea, in general, is well investigated but the epidemiology of Functional Diarrhoea (FDr) as a disease entity has not been adequately evaluated globally, and more especially, in the sub-Saharan African population.

Aim: To determine the prevalence and risk factors of FDr, and the associated quality of life in a Nigerian community.

Materials and Methods: The study was a community-based cross-sectional survey involving 515 consenting adults aged 18-70 years. Data collection was done from February to March 2019. Ten participants were excluded because of inappropriately filled questionnaires, thus leaving a total of 505 subjects. The research instrument contained sociodemographic information, the Rome IV Functional Bowel Disorder questionnaire, the Short Form 12, version 2 Health Survey (SF-12v2) questionnaire, the Beck Depression and Anxiety Inventories, the Pittsburgh Sleep Quality Index (PSQI), and the Early Trauma Inventory-Self Report. Respondents who were positive for FDr were the cases while those who had no FDr were the controls in the data analysis. Independent Student t-test was used to compare means. The odds ratios of prospective risk factors of FDr were calculated with logistic regression. Odds Ratios (OR) > 1 and p-value =0.05 were considered significant.

Results: The mean age of the participants was 32.7±12.9 years. Six participants {1.2% (95% CI, 0.4%-2.4%)} had FDr with a 1:2 Male/Female ratio. Functional diarrhoea had a statistically significant association with depression (18.0±12.8 vs 8.2±9.5, p-value=0.021) only among the possible risk factors considered. The mean SF-12v2 scale scores, except Vitality, were lower in subjects with FDr than the controls, though only Social Functioning was statistically significant (p-value=0.003).

Conclusion: The prevalence of FDr is low in the present study population. The disease is associated with depression and it impacts the Health-Related Quality of Life (HRQoL) negatively

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Jemilohun,A. ELIKWU,C. Ranajit,B. Adegboyega,C.O Jens,C.F Yinka,M.S . (2020). Functional Diarrhoea in a Nigerian Community: Prevalence, Risk Factors and Associated Quality of Life, 14 (), 1-1.

Jemilohun,A. ELIKWU,C. Ranajit,B. Adegboyega,C.O Jens,C.F Yinka,M.S . "Functional Diarrhoea in a Nigerian Community: Prevalence, Risk Factors and Associated Quality of Life" 14, no (), (2020): 1-1.

Jemilohun,A. and ELIKWU,C. and Ranajit,B. and Adegboyega,C.O and Jens,C.F and Yinka,M.S and . (2020). Functional Diarrhoea in a Nigerian Community: Prevalence, Risk Factors and Associated Quality of Life, 14 (), pp1-1.

JemilohunA, ELIKWUC, RanajitB, AdegboyegaCO, JensCF, YinkaMS, . Functional Diarrhoea in a Nigerian Community: Prevalence, Risk Factors and Associated Quality of Life. 2020, 14 ():1-1.

Jemilohun,Abiodun , ELIKWU,Charles , Ranajit,Bandyopadhyay , Adegboyega,C Odebode, Jens,C Frisvad, and Yinka,M Somorin . "Functional Diarrhoea in a Nigerian Community: Prevalence, Risk Factors and Associated Quality of Life", 14 . (2020) : 1-1.

J.Abiodun E.Charles R.Bandyopadhyay A.C Odebode J.C Frisvad & Y.M Somorin , "Functional Diarrhoea in a Nigerian Community: Prevalence, Risk Factors and Associated Quality of Life" vol.14, no., pp. 1-1, 2020.

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