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DIAZOXIDE USE FOR NEONATAL HYPERINSULINAEMIC HYPOGLYCAEMIA IN A LOW-RESOURCE SETTING: A CASE REPORT.

Authors: ADEKOYA Adesola , Adekanye E, ABOLURIN Olufunmilola , Adebawojo , Ajayi , Ajibola Ed

Publication Type: Journal article

Journal: Annals Of Health Research

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Abstract

The management of neonatal hyperinsulinaemic hypoglycaemia remains a major challenge in hospitalized newborns globally. Diazoxide is one of the recommended therapeutic options. We report a late preterm, male infant of a diabetic mother who suffered severe perinatal asphyxia and had persistent hypoglycaemia requiring progressively increasing intravenous glucose concentrations to as high as 12.5 mg/kg/minute along with intravenous hydrocortisone administration. A critical sample revealed inappropriately high serum insulin, inappropriately low serum cortisol and growth hormone responses. Urinalysis was negative for ketones. With the persistence of hypoglycaemia, oral diazoxide at 5 mg/kg/day with oral hydrochlorothiazide was administered. The infant was diazoxide-responsive with complete resolution of hypoglycaemia. Diazoxide therapy was discontinued after 14 days and he was discharged after one month of admission. This report emphasizes the importance of diazoxide in the management of neonatal transient hyperinsulinaemic hypoglycaemia. The availability and cost of diazoxide, as well as the endocrine and metabolic tests, are major concerns in resource-poor settings.

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ADEKOYA,A. Adekanye,T.E ABOLURIN,O. Adebawojo,O. Ajayi,F. Ajibola,E. . (2020). DIAZOXIDE USE FOR NEONATAL HYPERINSULINAEMIC HYPOGLYCAEMIA IN A LOW-RESOURCE SETTING: A CASE REPORT., 6 (), 338-338.

ADEKOYA,A. Adekanye,T.E ABOLURIN,O. Adebawojo,O. Ajayi,F. Ajibola,E. . "DIAZOXIDE USE FOR NEONATAL HYPERINSULINAEMIC HYPOGLYCAEMIA IN A LOW-RESOURCE SETTING: A CASE REPORT." 6, no (), (2020): 338-338.

ADEKOYA,A. and Adekanye,T.E and ABOLURIN,O. and Adebawojo,O. and Ajayi,F. and Ajibola,E. and . (2020). DIAZOXIDE USE FOR NEONATAL HYPERINSULINAEMIC HYPOGLYCAEMIA IN A LOW-RESOURCE SETTING: A CASE REPORT., 6 (), pp338-338.

ADEKOYAA, AdekanyeTE, ABOLURINO, AdebawojoO, AjayiF, AjibolaE, . DIAZOXIDE USE FOR NEONATAL HYPERINSULINAEMIC HYPOGLYCAEMIA IN A LOW-RESOURCE SETTING: A CASE REPORT.. 2020, 6 ():338-338.

ADEKOYA,Adesola , Adekanye,T E, ABOLURIN,Olufunmilola , Adebawojo,Oo , Ajayi,Fg , and Ajibola,Ed . "DIAZOXIDE USE FOR NEONATAL HYPERINSULINAEMIC HYPOGLYCAEMIA IN A LOW-RESOURCE SETTING: A CASE REPORT.", 6 . (2020) : 338-338.

A.Adesola A.T E A.Olufunmilola A.Oo A.Fg & A.Ed , "DIAZOXIDE USE FOR NEONATAL HYPERINSULINAEMIC HYPOGLYCAEMIA IN A LOW-RESOURCE SETTING: A CASE REPORT." vol.6, no., pp. 338-338, 2020.

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