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Impaired Antioxidant-Defence Status in Nigerian Children with Elevated Blood Lead Levels: A Possible Predisposing Factor to Chronic Diseases.

Authors: NWOBI Nnenna , Onyinyechi Nwaolikpe, Maria-goretti , Oluwaseyi Sodeinde, Florence Nneka Elele

Publication Type: Journal article

Journal: Journal Of Krishna Institute Of Medical Science University

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Abstract

Background: Lead, a prime environmental toxicant and multi-organ poison, exerts its toxicity through interaction with essential metals and the generation of free radicals. Aim and Objectives: To explore and elucidate possible interaction dynamics between lead and the antioxidant-defence status in apparently healthy children with Elevated Blood Lead Level (EBLL) in Ibadan, South-West, Nigeria. Material and Methods: Three-hundred-and-nine apparently healthy, public primary school children were grouped into 169 children with EBLL (BLL > 5µg/dL) and 140 control (BLL? 5µg/dL). Blood lead (Pb), plasma enzymatic antioxidants [Superoxide Dismutase (SOD) and Glutathione Peroxidase (GPx) activities], antioxidant metals [Copper (Cu), Zinc (Zn), Selenium (Se)], and oxidative stress parameters [Total Antioxidant Potential (TAP), Total Plasma Peroxide (TPP) and Oxidative Stress Index (OSI)] were determined. Results: Levels of Pb, Zn, Se, TPP and OSI increased while SOD, GPx and TAP decreased in children with EBLL compared with control (p<0> 0.05). Lead associated positively with Se, TPP and OSI (p<0>0.05).
Conclusion: There was impaired antioxidant-defence status in children with EBLLs which may predispose them to chronic diseases if unresolved.

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NWOBI,N. Onyinyechi,N.N Maria-goretti,E. Oluwaseyi,A.S Florence,N.E . (2020). Impaired Antioxidant-Defence Status in Nigerian Children with Elevated Blood Lead Levels: A Possible Predisposing Factor to Chronic Diseases., 9 (), 1-1.

NWOBI,N. Onyinyechi,N.N Maria-goretti,E. Oluwaseyi,A.S Florence,N.E . "Impaired Antioxidant-Defence Status in Nigerian Children with Elevated Blood Lead Levels: A Possible Predisposing Factor to Chronic Diseases." 9, no (), (2020): 1-1.

NWOBI,N. and Onyinyechi,N.N and Maria-goretti,E. and Oluwaseyi,A.S and Florence,N.E and . (2020). Impaired Antioxidant-Defence Status in Nigerian Children with Elevated Blood Lead Levels: A Possible Predisposing Factor to Chronic Diseases., 9 (), pp1-1.

NWOBIN, OnyinyechiNN, Maria-gorettiE, OluwaseyiAS, FlorenceNE, . Impaired Antioxidant-Defence Status in Nigerian Children with Elevated Blood Lead Levels: A Possible Predisposing Factor to Chronic Diseases.. 2020, 9 ():1-1.

NWOBI,Nnenna , Onyinyechi,N. Nwaolikpe, Maria-goretti,Ekundayo , Oluwaseyi,Adewunmi Sodeinde, and Florence,Nneka Elele . "Impaired Antioxidant-Defence Status in Nigerian Children with Elevated Blood Lead Levels: A Possible Predisposing Factor to Chronic Diseases.", 9 . (2020) : 1-1.

N.Nnenna O.N. Nwaolikpe M.Ekundayo O.Adewunmi Sodeinde & F.Nneka Elele , "Impaired Antioxidant-Defence Status in Nigerian Children with Elevated Blood Lead Levels: A Possible Predisposing Factor to Chronic Diseases." vol.9, no., pp. 1-1, 2020.

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