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Rifampicin resistance among patients with Tuberculosis at the Olabisi Onabanjo University Teaching Hospital, Sagamu

Authors: Olusoji , Janet , SODEINDE Kolawole , Adeola , Albert Salako

Publication Type: Journal article

Journal: Annals Of Health Research

ISSN Number:

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Abstract

Background: Tuberculosis (TB) is a major public health problem in Nigeria. The emergence of multidrug-resistant Tuberculosis
poses a threat to global Tuberculosis control and if not effectively addressed, may wipe out the achievements of previous efforts in
controlling Tuberculosis.
Objectives: To determine the prevalence and factors associated with rifampicin resistance among patients receiving care for TB at
the OlabisiOnabanjo University Teaching Hospital, Sagamu.
Methods: A retrospective study of presumptive Tuberculosis cases managed between January 2013 and December 2016 at the
Directly Observed Treatment clinic, OlabisiOnabanjoUniversity Teaching Hospital Sagamu, Ogun State, Nigeria, was done. One
sputum sample was obtained from each patient for the Gene Xpert® test to diagnose TB and to determine rifampicin resistance
among patients with confirmed Mycobacterium tuberculosis infection. HIV screening was also carried out on all the patients using
HIV Rapid Test kits. The sociodemographic data were retrieved from the presumptive Tuberculosis register.
Results: A total of 1572 presumptive TB patients was screened for TB, out of which 187 (11.8%) were confirmed to be infected with
Mycobacterium tuberculosis (MTB). A total of 20 (10.7%) of the 187 MTB patients had rifampicin resistance using the Gene Xpert®
method. The Rifampicin resistance rate was significantly associated with re-treatment TB category, but not with age, sex or HIV
status.
Conclusion: The study showed rifampicin drug resistance among confirmed TB patients. There is a need to decentralise the use of
Gene Xpert® test for TB to the peripheral facilities and make it a point of care test for presumptive TB patients

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Olusoji,D. Janet,B. SODEINDE,K. Adeola,E. Albert,S. . (2018). Rifampicin resistance among patients with Tuberculosis at the Olabisi Onabanjo University Teaching Hospital, Sagamu, 4 (), 53-53.

Olusoji,D. Janet,B. SODEINDE,K. Adeola,E. Albert,S. . "Rifampicin resistance among patients with Tuberculosis at the Olabisi Onabanjo University Teaching Hospital, Sagamu" 4, no (), (2018): 53-53.

Olusoji,D. and Janet,B. and SODEINDE,K. and Adeola,E. and Albert,S. and . (2018). Rifampicin resistance among patients with Tuberculosis at the Olabisi Onabanjo University Teaching Hospital, Sagamu, 4 (), pp53-53.

OlusojiD, JanetB, SODEINDEK, AdeolaE, AlbertS, . Rifampicin resistance among patients with Tuberculosis at the Olabisi Onabanjo University Teaching Hospital, Sagamu. 2018, 4 ():53-53.

Olusoji,Daniel , Janet,Bamidele , SODEINDE,Kolawole , Adeola,Ekundayo , and Albert,Salako . "Rifampicin resistance among patients with Tuberculosis at the Olabisi Onabanjo University Teaching Hospital, Sagamu", 4 . (2018) : 53-53.

O.Daniel J.Bamidele S.Kolawole A.Ekundayo & A.Salako , "Rifampicin resistance among patients with Tuberculosis at the Olabisi Onabanjo University Teaching Hospital, Sagamu" vol.4, no., pp. 53-53, 2018.

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