Babcock University Research Portal

In-vitro antisickling and sickling-reversal activities of Carica papaya fruit at different stages of ripening

Authors: ADETAYO Adekunle , ADETAYO Modupe , SHOKUNBI Olutayo , Tang , Beth Payne

Publication Type: Journal article

Journal: Babcock University Medical Journal

ISSN Number:

Downloads

Views

Abstract

Objective: Sickle cell disease (SCD) is a haemoglobinopathy that causes several clinical complications. Unripe Carica papaya has been shown to possess antisickling activity that could reduce these complications. This study aimed to examine the presence of antisickling and sickling-reversal activities of aqueous extracts and ethyl acetate fractions of C. papaya fruit at different stages of ripening.
Methods: Unripe, partly ripe and fully ripe fruits were quantitatively screened for some phytochemicals using standard methods. Blood samples from sickle cell patients were used to investigate antisickling and sickling reversal activities of aqueous extracts and ethyl acetate fractions of the fruits. Data were analysed using one-way ANOVA. p-value was set at 0.05.
Results: Phytochemicals such as alkaloids, saponins, tannins, flavonoids and polyphenols were found in varying concentrations in C. papaya fruit at the different stages of ripening. All extracts and fractions showed antisickling and sickling-reversal activities with the ethyl acetate fraction of partly ripe C. papaya being most effective.
Conclusion: The study showed that C. papaya fruit at different stages of ripening contains antisickling and sickling-reversal activities which may help reduce the associated complications of SCD when consumed by affected individuals.

Access to Documents

External Link
Download
Digital Object Identifier

Keywords

ADETAYO,A. ADETAYO,M. SHOKUNBI,O. Tang,L. Beth,P. . (2020). In-vitro antisickling and sickling-reversal activities of Carica papaya fruit at different stages of ripening, 2 (), 10-10.

ADETAYO,A. ADETAYO,M. SHOKUNBI,O. Tang,L. Beth,P. . "In-vitro antisickling and sickling-reversal activities of Carica papaya fruit at different stages of ripening" 2, no (), (2020): 10-10.

ADETAYO,A. and ADETAYO,M. and SHOKUNBI,O. and Tang,L. and Beth,P. and . (2020). In-vitro antisickling and sickling-reversal activities of Carica papaya fruit at different stages of ripening, 2 (), pp10-10.

ADETAYOA, ADETAYOM, SHOKUNBIO, TangL, BethP, . In-vitro antisickling and sickling-reversal activities of Carica papaya fruit at different stages of ripening. 2020, 2 ():10-10.

ADETAYO,Adekunle , ADETAYO,Modupe , SHOKUNBI,Olutayo , Tang,Lee , and Beth,Payne . "In-vitro antisickling and sickling-reversal activities of Carica papaya fruit at different stages of ripening", 2 . (2020) : 10-10.

A.Adekunle A.Modupe S.Olutayo T.Lee & B.Payne , "In-vitro antisickling and sickling-reversal activities of Carica papaya fruit at different stages of ripening" vol.2, no., pp. 10-10, 2020.

Access to Documents

Keywords

About Us

Admissions

Contact Us

Policies

ALUMNI

STUDENT POPULATION