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Long Term Amlodipine Administration Caused Infertility in Wistar Rat: A Paradoxically Safe Contraceptive

Authors: ADELODUN Stephen , OLATUNJI SUNDAY YINKA , & Owolabi Joshua

Publication Type: Journal article

Journal: International Journal Of Medicine And Biomedical Research

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Abstract

Background: Alarming population increase with fewer resources in this century is undisputable especially in under-developed countries. Hence, the need for efficient and affordable birth control which majority don’t have access to, unfortunately. Aim: This study investigated the paradoxical anti-fertility effect of amlodipine in Wistar rats with a view to proposing it as a safe male contraceptive. Methods: Twenty (20) male adult rats (120-170g) were gotten from the animal house of Babcock University, Ogun State, Nigeria. The rats were randomly grouped into A-D (n = 5). Group A was given 0.5ml of distilled water while groups B-D were given 0.1mg/kg, 0.2mg/kg and 0.6mg/kg of amlodipine (dissolved in water) respectively, orally for 28 days. Blood was collected through ocular puncture into plain bottles, centrifuged at 4000 revolutions/minute for 15 minutes. Plasma was decanted and analyzed for hormonal assays. Rats were sacrificed 24 hours after last administration by cervical dislocation. Sperm was collected from the epididymis for analysis. Testes were excised and fixed in Bouin’s fluid for histological investigations. Data were analyzed using One-way ANOVA using Graph pad Prism and Student Newman- Keuls post- hoc test for multiple comparison. Result: There was significant increased body weight, feed and water intake and increased levels of testosterone, luteinizing and follicle stimulating hormones in the treated groups. There is no significant difference in sperm motility but a significant decrease and increase in sperm count and live/death ratio respectively across the treated groups (p<0>

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ADELODUN,S. OLATUNJI,S. Owolabi,J. . (2019). Long Term Amlodipine Administration Caused Infertility in Wistar Rat: A Paradoxically Safe Contraceptive, 81 (), 1-1.

ADELODUN,S. OLATUNJI,S. Owolabi,J. . "Long Term Amlodipine Administration Caused Infertility in Wistar Rat: A Paradoxically Safe Contraceptive" 81, no (), (2019): 1-1.

ADELODUN,S. and OLATUNJI,S. and Owolabi,J. and . (2019). Long Term Amlodipine Administration Caused Infertility in Wistar Rat: A Paradoxically Safe Contraceptive, 81 (), pp1-1.

ADELODUNS, OLATUNJIS, OwolabiJ, . Long Term Amlodipine Administration Caused Infertility in Wistar Rat: A Paradoxically Safe Contraceptive. 2019, 81 ():1-1.

ADELODUN,Stephen , OLATUNJI,SUNDAY YINKA , and Owolabi,Joshua . "Long Term Amlodipine Administration Caused Infertility in Wistar Rat: A Paradoxically Safe Contraceptive", 81 . (2019) : 1-1.

A.Stephen O.SUNDAY YINKA & O.Joshua , "Long Term Amlodipine Administration Caused Infertility in Wistar Rat: A Paradoxically Safe Contraceptive" vol.81, no., pp. 1-1, 2019.

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