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Progesterone Improve Streptozotocin-Induced Prefrontal Nissl Substance Deficit

Authors: Adetunji Opeyemi , Oluwole Akinola, Afolayan Sunmbo

Publication Type: Journal article

Journal: Austin Journal Of Anatomy

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Abstract

Background: Nissl bodies are essential to the well-being of a neuron; decrease in the Nissl bodies of a neuron indicates neural degeneration, neurodegenerative diseases cause neural cells to lose both the functional and sensory abilities. This study investigate the activities of progesterone on Nissl substance of the prefrontal cortex cells in Adult Male Wistar Rats acutely exposed to a streptozotocin. Materials and Methods: Forty eight (48) Rattus novergicus, weighing 220±30g were randomly selected into six groups. Group 1 (0.2ml Normal saline for 14 days), Group 2 (low dose of 4mg/kg of progesterone for 7 days), Group 3 (8mg/kg of progesterone for 7 days), Group 4 (double dose of 30mg/kg of streptozotocin only), Group 5 (double dose of 30mg/kg of streptozotocin start followed by 4mg/kg of progesterone for 7 days), Group 6 (double dose of 30mg/ kg of streptozotocin start followed 8mg/kg of progesterone for 7 days). The administration was intra-peritoneal and all animals were euthanized using 20mg/ kg of intramuscular ketamine, cardially perfused with 4% paraformaldehyde, the brains and prefrontal cortex was removed for biochemical and histological analysis. Results: Between three to seven days Streptozotocin administration caused degeneration of beta cells, in rats Groups 4, 5, and 6 shows induceddiabetic symptoms via tests. Histological structure of the prefrontal cortex tissue of the rats’ brain sampling indicates intoxication with streptozotocin cause chromatolysis in the brain sampling. Conclusion: Progesterone proved to regulate the activities of stress markers and play protective role in some parts of the prefrontal cortex Nissl substance of the Rattus novergicus.

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Adetunji,O. Oluwole,B.A Afolayan,S. . (2020). Progesterone Improve Streptozotocin-Induced Prefrontal Nissl Substance Deficit, 7 (), 1-1.

Adetunji,O. Oluwole,B.A Afolayan,S. . "Progesterone Improve Streptozotocin-Induced Prefrontal Nissl Substance Deficit" 7, no (), (2020): 1-1.

Adetunji,O. and Oluwole,B.A and Afolayan,S. and . (2020). Progesterone Improve Streptozotocin-Induced Prefrontal Nissl Substance Deficit, 7 (), pp1-1.

AdetunjiO, OluwoleBA, AfolayanS, . Progesterone Improve Streptozotocin-Induced Prefrontal Nissl Substance Deficit. 2020, 7 ():1-1.

Adetunji,Opeyemi , Oluwole,Busayo Akinola, and Afolayan,Sunmbo . "Progesterone Improve Streptozotocin-Induced Prefrontal Nissl Substance Deficit", 7 . (2020) : 1-1.

A.Opeyemi O.Busayo Akinola & A.Sunmbo , "Progesterone Improve Streptozotocin-Induced Prefrontal Nissl Substance Deficit" vol.7, no., pp. 1-1, 2020.

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