Babcock University Research Portal

Cardiovascular Effects of Caffeine in Rabbits Involve Beta-1 Adrenergic Receptor Activation

Authors: Nabofa Enivwenaye

Publication Type: Journal article

Journal: Journal Of Caffeine And Adenosine Research

ISSN Number:

Downloads

Views

Abstract

Background: Mechanistic studies indicate that adenosine receptor antagonism may not account for the
mechanism of caffeine’s cardiovascular action in chronic caffeine users. We, thus, aimed at examining
the possible role of catecholamine mechanism in caffeine’s cardiovascular action during habitual use.
Materials and Methods: Adult male New Zealand rabbits were divided into three groups (n = 5). Group I
rabbits were untreated and served as control whereas groups II and III rabbits were administered with 2 and
6 mg/kg caffeine, respectively, for 28 days. After anesthesia arterial pressure, electrocardiogram and heart
rate were recorded. Blood and cardiac tissue samples were collected for analysis.
Results: After 28 days of caffeine treatment, cardiovascular parameters were significantly altered. There
were increases in catecholamine level, beta-1 receptor expression, adenylate cyclase 9 immuno-reactivity,
and cardiac cyclic adenosine monophosphate concentrations.
Conclusion: This study demonstrates that caffeine’s cardiovascular action in rabbits involves the activation
of the beta-1 adrenergic pathway.

Access to Documents

External Link
Download
Digital Object Identifier

Keywords

Nabofa,E. . (2020). Cardiovascular Effects of Caffeine in Rabbits Involve Beta-1 Adrenergic Receptor Activation, 102 (), 84-84.

Nabofa,E. . "Cardiovascular Effects of Caffeine in Rabbits Involve Beta-1 Adrenergic Receptor Activation" 102, no (), (2020): 84-84.

Nabofa,E. and . (2020). Cardiovascular Effects of Caffeine in Rabbits Involve Beta-1 Adrenergic Receptor Activation, 102 (), pp84-84.

NabofaE, . Cardiovascular Effects of Caffeine in Rabbits Involve Beta-1 Adrenergic Receptor Activation. 2020, 102 ():84-84.

Nabofa,Enivwenaye , . "Cardiovascular Effects of Caffeine in Rabbits Involve Beta-1 Adrenergic Receptor Activation", 102 . (2020) : 84-84.

N.Enivwenaye , "Cardiovascular Effects of Caffeine in Rabbits Involve Beta-1 Adrenergic Receptor Activation" vol.102, no., pp. 84-84, 2020.

Access to Documents

Keywords

About Us

Admissions

Contact Us

Policies

ALUMNI

STUDENT POPULATION