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Urinary Bladder Thickness, Tumor Antigen, and Lower Urinary Tract Symptoms in a Low Schistosoma haematobium Endemic Rural Community of Nigeria

Authors: ADEFALUJO Adekunle , AYENI Kolawole , NWOZICHI Chinomso , & Nabofa Enivwenaye

Publication Type: Journal article

Journal: Urological Science

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Abstract

Objective: Bladder tumor antigen (BTA) is a common biomarker for urothelial carcinoma while bladder wall thickening (BWT) is a sign
of urinary bladder irritation which suggests cystitis or early?stage bladder cancer pathology, most especially in the absence of bladder outlet
obstruction. The aim of this study was to find the incidence of urinary bladder thickness and evaluate the relationship between BTA and BWT
in a low schistosomiasis?endemic Nigerian village. Materials and Methods: The study was descriptive and cross?sectional. Freshly passed
mid?day urine samples of 56 individuals were screened using chemical reagent strips and then diagnosed microscopically for Schistosoma
haematobium. Subsequent follow?up involving ultrasound examination was carried out on distended bladder. The lower urinary tract
symptoms (LUTS) were also recorded. Urinary BTA analysis was carried out on the urine samples using enzyme?linked immunosorbent assay.
Results: The prevalence of urogenital schistosomiasis in the area was 3.6%. The overall prevalence of human BTA and BWT in the individuals
was 44.6 and 35.7%, respectively. The LUTS were associated with BWT (P = 0.004; odds ratio = 6.0; 95% confidence interval = 1.8–20.3).
BTA, BWT, and LUTS were not sex and age dependent (P > 0.05). In addition, there was no association between urinary BTA, BWT, and
LUTS (P > 0.05). The sensitivity of BWT and LUTS (60.0%) was improved than when either was used to diagnose BTA. Conclusion: The
high occurrence of BTA and BWT in the individuals suggests that they may be prone to urothelial carcinoma and urinary bladder irritation,
respectively. The role of urogenital schistosomiasis in urinary BTA levels needs to be further explored.

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ADEFALUJO,A. AYENI,K. NWOZICHI,C. Nabofa,E. . (2018). Urinary Bladder Thickness, Tumor Antigen, and Lower Urinary Tract Symptoms in a Low Schistosoma haematobium Endemic Rural Community of Nigeria, 29 (), 151-151.

ADEFALUJO,A. AYENI,K. NWOZICHI,C. Nabofa,E. . "Urinary Bladder Thickness, Tumor Antigen, and Lower Urinary Tract Symptoms in a Low Schistosoma haematobium Endemic Rural Community of Nigeria" 29, no (), (2018): 151-151.

ADEFALUJO,A. and AYENI,K. and NWOZICHI,C. and Nabofa,E. and . (2018). Urinary Bladder Thickness, Tumor Antigen, and Lower Urinary Tract Symptoms in a Low Schistosoma haematobium Endemic Rural Community of Nigeria, 29 (), pp151-151.

ADEFALUJOA, AYENIK, NWOZICHIC, NabofaE, . Urinary Bladder Thickness, Tumor Antigen, and Lower Urinary Tract Symptoms in a Low Schistosoma haematobium Endemic Rural Community of Nigeria. 2018, 29 ():151-151.

ADEFALUJO,Adekunle , AYENI,Kolawole , NWOZICHI,Chinomso , and Nabofa,Enivwenaye . "Urinary Bladder Thickness, Tumor Antigen, and Lower Urinary Tract Symptoms in a Low Schistosoma haematobium Endemic Rural Community of Nigeria", 29 . (2018) : 151-151.

A.Adekunle A.Kolawole N.Chinomso & N.Enivwenaye , "Urinary Bladder Thickness, Tumor Antigen, and Lower Urinary Tract Symptoms in a Low Schistosoma haematobium Endemic Rural Community of Nigeria" vol.29, no., pp. 151-151, 2018.

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