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Vancomycin intermediate resistant Staphylococcus aureus in the nasal cavity of asymptomatic individuals: a potential public health challenge

Authors: ADEOYE-ISIJOLA Morenike , OLAJUYIGBE Olufunmiso , Ayomide Afolabi, Olasumbo Kukoy, Kuyoro Yewande

Publication Type: Journal article

Journal: African Health Sciences

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Abstract

Abstract
Background: The potential of transmitting multidrug resistant Staphylococcus aureus from asymptomatic individuals to healthy
individuals could constitute a great challenge to antimicrobial therapy.
Methods: The antibiograms of the S. aureus from asymptomatic individuals were determined by disk diffusion and agar
dilution assay techniques with different antibiotics and vancomycin.
Results: Of the 152 S. aureus isolated, (59)38.8% isolates were multi-drug resistant strains. Streptomycin was the most
effective and inhibited (135)88.82% of the isolates while ceftazidime inhibited (24)15.8% of the isolates. While (82)54.0%
of the isolates inhibited by cefuroxime had resistant colonies within their inhibition zones (Rc) and o?oxacin inhibited
(100)65.8% of the isolates without having resistant colonies within the inhibition zones, ceftazidime inhibited (7)4.6% of
the isolates with resistant colonies within the inhibition zones. Subjecting the isolates to vancomycin showed that (27)17.8%
were resistant to 2 µg/ml, (43)28.3% were resistant to 4 µg/ml and (27)17.8% of the isolates were simultaneously resistant
to both concentrations of vancomycin. Although (100)65.8% of the isolates had MARindex ?0.2, (52)34.2% of the isolates
had MAR
index ? 0.2 and (65)428% of the isolates were considered multidrug resistant strains.
Conclusion: The isolation of multi-drug and vancomycin intermediate resistant strains of S. aureus in high percentage, in
this study, presents a great threat to clinicians and general populace. The vancomycin intermediate resistant S. aureus (VISA)
in asymptomatic individuals could be a critical concern to the therapeutic dilemma to be added to the presence of multi-drug
resistance. A more sustainable therapy must be in place to prevent its dissemination or the outbreak of its infection.
Keywords: Antibacterial activity, multidrug resistance, VRSA, VISA, vancomycin

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ADEOYE-ISIJOLA,M. OLAJUYIGBE,O. Ayomide,R.A Olasumbo,B.K Kuyoro,Y. . (2020). Vancomycin intermediate resistant Staphylococcus aureus in the nasal cavity of asymptomatic individuals: a potential public health challenge, 20 (), 1109-1109.

ADEOYE-ISIJOLA,M. OLAJUYIGBE,O. Ayomide,R.A Olasumbo,B.K Kuyoro,Y. . "Vancomycin intermediate resistant Staphylococcus aureus in the nasal cavity of asymptomatic individuals: a potential public health challenge" 20, no (), (2020): 1109-1109.

ADEOYE-ISIJOLA,M. and OLAJUYIGBE,O. and Ayomide,R.A and Olasumbo,B.K and Kuyoro,Y. and . (2020). Vancomycin intermediate resistant Staphylococcus aureus in the nasal cavity of asymptomatic individuals: a potential public health challenge, 20 (), pp1109-1109.

ADEOYE-ISIJOLAM, OLAJUYIGBEO, AyomideRA, OlasumboBK, KuyoroY, . Vancomycin intermediate resistant Staphylococcus aureus in the nasal cavity of asymptomatic individuals: a potential public health challenge. 2020, 20 ():1109-1109.

ADEOYE-ISIJOLA,Morenike , OLAJUYIGBE,Olufunmiso , Ayomide,Rachael Afolabi, Olasumbo,Bilikisu Kukoy, and Kuyoro,Yewande . "Vancomycin intermediate resistant Staphylococcus aureus in the nasal cavity of asymptomatic individuals: a potential public health challenge", 20 . (2020) : 1109-1109.

A.Morenike O.Olufunmiso A.Rachael Afolabi O.Bilikisu Kukoy & K.Yewande , "Vancomycin intermediate resistant Staphylococcus aureus in the nasal cavity of asymptomatic individuals: a potential public health challenge" vol.20, no., pp. 1109-1109, 2020.

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