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Antimycotic and cytotoxicological potentials of Acacia mearnsii De wild. stem bark extract: in vitro assessment

Authors: ADEOYE-ISIJOLA Morenike , OLAJUYIGBE Olufunmiso , Janet Bamidele

Publication Type: Journal article

Journal: Kragujevac Journal Of Science

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Abstract

ABSTRACT: Despite using antimycotic drugs in the treatment of dermatomycoses as an
age long practice, the fungicidal activities of indigenous plants on spores of
dermatophytes from germinating in vitro need to be investigated further. In this study,
methanol extract of Acacia mearnsii was assessed for its antifungal activity against
dermatophytic pathogenic fungi by agar diffusion and broth dilution methods. The
cytotoxicity activity of the extract was determined by the brine shrimp lethality assay.
The study showed that the mean ± standard deviation of the inhibition zones ranged
between 13 and 24 ± 0.58 mg/ml and the activity of the extract was concentration
dependent. While the minimum inhibitory concentration (MIC) was 0.3125 – 2.5 mg/ml,
the minimum fungicidal concentration (MFC) values ranged between 0.3125 mg/ml and 5
mg/ml. The susceptibility of the yeast to the extract was more than those of the molds.
The MIC of the yeasts ranged between 0.3125 and 1.25 mg/ml while those of the molds
ranged between 0.625 and 2.5 mg/ml. The mechanism of antibiosis showed that the
extract was 7.69% fungistatic and 92.31% fungicidal wielding more killing effects on the
fungi than potentiating their growth. The cytotoxicity assay showed that the crude
methanolic extract with the LC50 being 101.59 µg/ml was pharmacologically active and
nontoxic (LC50 > 100 ?g/ml). The antifungal activity of this plant can be exploited as an
alternative or complementary means of treating fungal infections to eliminate fungal
spread. The study further justified the folkloric use of A. mearnsii in the treatment of a
variety of microbial infections.

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ADEOYE-ISIJOLA,M. OLAJUYIGBE,O. Janet,B. . (2019). Antimycotic and cytotoxicological potentials of Acacia mearnsii De wild. stem bark extract: in vitro assessment, 41 (), 87-87.

ADEOYE-ISIJOLA,M. OLAJUYIGBE,O. Janet,B. . "Antimycotic and cytotoxicological potentials of Acacia mearnsii De wild. stem bark extract: in vitro assessment" 41, no (), (2019): 87-87.

ADEOYE-ISIJOLA,M. and OLAJUYIGBE,O. and Janet,B. and . (2019). Antimycotic and cytotoxicological potentials of Acacia mearnsii De wild. stem bark extract: in vitro assessment, 41 (), pp87-87.

ADEOYE-ISIJOLAM, OLAJUYIGBEO, JanetB, . Antimycotic and cytotoxicological potentials of Acacia mearnsii De wild. stem bark extract: in vitro assessment. 2019, 41 ():87-87.

ADEOYE-ISIJOLA,Morenike , OLAJUYIGBE,Olufunmiso , and Janet,Bamidele . "Antimycotic and cytotoxicological potentials of Acacia mearnsii De wild. stem bark extract: in vitro assessment", 41 . (2019) : 87-87.

A.Morenike O.Olufunmiso & J.Bamidele , "Antimycotic and cytotoxicological potentials of Acacia mearnsii De wild. stem bark extract: in vitro assessment" vol.41, no., pp. 87-87, 2019.

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