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In vitro influence of metronidazole on the activities of ciprofloxacin against clinically important bacterial isolates

Authors: ADEOYE-ISIJOLA Morenike , OLAJUYIGBE Olufunmiso , Osopale Babasola

Publication Type: Journal article

Journal: Gsc Biological And Pharmaceutical Sciences

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Abstract

Abstract
A continued in vitro investigation into drug-drug interaction is necessary to avert dangerous drug combinations and
achieve effective therapy at lower drug concentrations. In this study, the interactions of ciprofloxacin and metronidazole
and the effectiveness of the antibacterial combinations against selected bacterial strains were investigated by agar
diffusion, macrobroth dilution and the checkerboard assay methods. The results showed that the combined antibiotics
had better antibacterial effects than those produced by the ciprofloxacin while no inhibition zone was produced by
metronidazole at the concentrations used. At the highest concentration of the combination, the inhibition zones ranged
between 28±1.00 mm and 37±1.00 mm while Plesiomonas shigelloidis was highly resistant. While the minimum
inhibitory concentrations (MICs) of ciprofloxacin ranged between 0.05 and 3.13 µg/ml and those of metronidazole were
between 15.63 and 62.5 µg/ml, the MICs for the antibacterial combinations were between 0.02/0.12 and 3.13/1.56
(Cip/Met) µg/ml against all the test microorganisms. The percentage reduction in the MICs showed that while the MICs
of ciprofloxacin were reduced by between 0 and 96.87%, those of metronidazole were reduced by between 0 and 99.80
% when the two antibiotics were combined. The interaction of ciprofloxacin and metronidazole was more of synergy
(55.56 %) than additive/indifference (44.4%). The FICI indicating synergistic interaction ranged between 0.035 and
0.375, the FICI indicating additive/indifference interactions ranged between 0.532 and 1.25. No antagonistic interaction
was recorded. The lack of antagonism between these antibacterial agents suggested that their combination would be an
improved therapy over the use of each antibiotic individually and may be useful in attaining better therapeutic effects
in infections where polymicrobial and resistant bacterial strains may be involved.

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ADEOYE-ISIJOLA,M. OLAJUYIGBE,O. Osopale,B. . (2019). In vitro influence of metronidazole on the activities of ciprofloxacin against clinically important bacterial isolates, 6 (), 31-31.

ADEOYE-ISIJOLA,M. OLAJUYIGBE,O. Osopale,B. . "In vitro influence of metronidazole on the activities of ciprofloxacin against clinically important bacterial isolates" 6, no (), (2019): 31-31.

ADEOYE-ISIJOLA,M. and OLAJUYIGBE,O. and Osopale,B. and . (2019). In vitro influence of metronidazole on the activities of ciprofloxacin against clinically important bacterial isolates, 6 (), pp31-31.

ADEOYE-ISIJOLAM, OLAJUYIGBEO, OsopaleB, . In vitro influence of metronidazole on the activities of ciprofloxacin against clinically important bacterial isolates. 2019, 6 ():31-31.

ADEOYE-ISIJOLA,Morenike , OLAJUYIGBE,Olufunmiso , and Osopale,Babasola . "In vitro influence of metronidazole on the activities of ciprofloxacin against clinically important bacterial isolates", 6 . (2019) : 31-31.

A.Morenike O.Olufunmiso & O.Babasola , "In vitro influence of metronidazole on the activities of ciprofloxacin against clinically important bacterial isolates" vol.6, no., pp. 31-31, 2019.

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