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Role of Progesterone Treatment on the Microanatomy of the Prefrontal Cortex of Streptozotocin - Induced Diabetic Wistar Rats

Authors: Adetunji Opeyemi , Adetunji Toyin, Sumbo , Akinola Oluwole Busayo

Publication Type: Journal article

Journal: Global Journal Of Pharmacology

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Abstract

Elucidation of progesterone effect on the prefrontal cortex of a streptozotocin-induced diabetic Wistar rats via comparison of changes in theoxidative stress, cyto-architecture of the prefrontal cortex of rats, levels of glucose and on the dosages of progesterone administered intra-peritoneal. Streptozotocin (STZ, 30mg/kg/b.w) double dosages were injected to mimic diabetes by degenerating beta cells within third to seventh days in adult male rats. There are eight rats per group and treatments included (STZ, received two doses of 30mg/kg/b.w Streptozotocin; STZ+LDP treatment received 30 mg/kg/b.w Streptozotocin and low dose progesterone (LDP, 4 mg/kg/b.w/day); STZ+HDP treatment received 30 mg/kg/b.w Streptozotocin and high dose progesterone (HDP, 8 mg/kg/b.w/day); LDP received 4 mg/kg/b.w/day progesterone; and HDP received 8 mg/kg/b.w/day progesterone while the control (CTR) and STZ treatments received no progesterone. In the study, blood glucose level increased in the diabetic animals in comparison with normal animals. Metabolically and histologically, comprising between diabetic and untreated rats showed that Streptozotocin caused degeneration in astrocytes and induced experimental diabetes while progesterone dosage induced ameliorative effect. In conclusion, progesterone protects and keeps the neurons in the brain, likewise proved that streptozotocin have a neurodegenerative effect.

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Adetunji,O. Adetunji,I.T Sumbo,A. Akinola,O.B . (2020). Role of Progesterone Treatment on the Microanatomy of the Prefrontal Cortex of Streptozotocin - Induced Diabetic Wistar Rats, 14 (), 9-9.

Adetunji,O. Adetunji,I.T Sumbo,A. Akinola,O.B . "Role of Progesterone Treatment on the Microanatomy of the Prefrontal Cortex of Streptozotocin - Induced Diabetic Wistar Rats" 14, no (), (2020): 9-9.

Adetunji,O. and Adetunji,I.T and Sumbo,A. and Akinola,O.B and . (2020). Role of Progesterone Treatment on the Microanatomy of the Prefrontal Cortex of Streptozotocin - Induced Diabetic Wistar Rats, 14 (), pp9-9.

AdetunjiO, AdetunjiIT, SumboA, AkinolaOB, . Role of Progesterone Treatment on the Microanatomy of the Prefrontal Cortex of Streptozotocin - Induced Diabetic Wistar Rats. 2020, 14 ():9-9.

Adetunji,Opeyemi , Adetunji,Iyabode Toyin, Sumbo,Afolayan , and Akinola,Oluwole Busayo . "Role of Progesterone Treatment on the Microanatomy of the Prefrontal Cortex of Streptozotocin - Induced Diabetic Wistar Rats", 14 . (2020) : 9-9.

A.Opeyemi A.Iyabode Toyin S.Afolayan & A.Oluwole Busayo , "Role of Progesterone Treatment on the Microanatomy of the Prefrontal Cortex of Streptozotocin - Induced Diabetic Wistar Rats" vol.14, no., pp. 9-9, 2020.

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