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Hemophagocytic lymphohistiocytosis in a Nigerian child: A review of the literature

Authors: JAGUN Omodele

Publication Type: Journal article

Journal: Annals Of Tropical Medicine And Public Health

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Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a rare, life?threatening, underdiagnosed hematologic disorder
that occurs from unregulated immune activation, extreme inflammation, and tissue damage. The major cause of
mortality in HLH is a delay in diagnosis and prompt initiation of treatment which occurs due to the variability of
the clinical manifestation of this disease entity. We present a case of a 17?year?old adolescent who presented with
fever, painful facial swelling that partially resolved with the initial use of intravenous dexamethasone. Diagnosis
of HLH was finally made and he had complete resolution of symptoms following appropriate treatment. With
careful search, there is no report of HLH in Nigeria and the possibility of missed diagnosis and underdiagnosis
cannot be ruled out. This case report of HLH is the first in Nigeria and due to the rarity of the disease the need to
raise more awareness is imperative as a high index of suspicion is required for diagnosis.

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JAGUN,O. . (2018). Hemophagocytic lymphohistiocytosis in a Nigerian child: A review of the literature, 11 (), 1-1.

JAGUN,O. . "Hemophagocytic lymphohistiocytosis in a Nigerian child: A review of the literature" 11, no (), (2018): 1-1.

JAGUN,O. and . (2018). Hemophagocytic lymphohistiocytosis in a Nigerian child: A review of the literature, 11 (), pp1-1.

JAGUNO, . Hemophagocytic lymphohistiocytosis in a Nigerian child: A review of the literature. 2018, 11 ():1-1.

JAGUN,Omodele , . "Hemophagocytic lymphohistiocytosis in a Nigerian child: A review of the literature", 11 . (2018) : 1-1.

J.Omodele , "Hemophagocytic lymphohistiocytosis in a Nigerian child: A review of the literature" vol.11, no., pp. 1-1, 2018.

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