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Biological activities and chemical composition of essential oil from Erythrina caffra Thunb. used in treatment of infections and complications associated with gastrointestinal infections in South Africa

Authors: OLAJUYIGBE Olufunmiso

Publication Type: Journal article

Journal: Heliyon

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Introduction:Essential oils from plants are recognized as one of the most promising secondary metabolites for thedevelopment of cheap and safer drugs. WhileErythrina caffrahas been prominently used in folk medicine for thetreatment of microbial infections, there is dearth of information on the pharmacological effectiveness andchemical composition of its essential oil. The study, therefore, aimed at identifying the chemical composition andbiological activities of the essential oil ofErythrina caffra.Methods:In this study, the essential oil was extracted with all-glass Clevenger. The antioxidant activities of theessential oil and antibacterial susceptibility assay by agar well diffusion techniques were assessed while GC-MSanalysis was performed to identify the chemical constituents of the essential oil.Results:The study showed that the radical scavenging activity of the essential oil increases as the concentration ofthe essential oil increases. All bacterial isolates were susceptible to essential oil with the exception ofSalmonellatyphimuriumandPseudomonas aeruginosaproducing inhibition zones ranging between 221.3 and 352.1 mmin the susceptible isolates. The GC-MS chromatogram indicated there are 35 bioactive compounds in the essentialoil and Caryophyllene oxide (53.54%), [1S-(1?,7?,8a?)]-1,2,3,5,6,7,8,8a-octa-1 - hydro-1,8a-dimethyl-7-(1-methylethenyl)-Naphthalene (7.81%), Kauran-18-al (6.49%), 10,10-Dimethyl-2,6-dimethylenebicy clo[7.2.0]undecan-5.beta.-ol (5.83%), 10s,11s-Himachala-3(12),4-diene (4.51%), Caryophyllene (3.65%) and 1- Hexanol(3.31%) were the most prominent compounds.Conclusion:Excessive production of free radicals or reactive oxygen species (ROS) causes oxidative stress anddisease. Oxidative stress resulting from imbalance between excessive generation of free radicals and inadequateantioxidant defense system has been linked to pathogenesis of many diseases. The essential oil ofE. caffrastembark extract possess antimicrobial and good antioxidant activities and its rich level of phytochemicals can be usedas either dietary or complementary agents.

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OLAJUYIGBE,O. . (2021). Biological activities and chemical composition of essential oil from Erythrina caffra Thunb. used in treatment of infections and complications associated with gastrointestinal infections in South Africa, 7 (), 1-1.

OLAJUYIGBE,O. . "Biological activities and chemical composition of essential oil from Erythrina caffra Thunb. used in treatment of infections and complications associated with gastrointestinal infections in South Africa" 7, no (), (2021): 1-1.

OLAJUYIGBE,O. and . (2021). Biological activities and chemical composition of essential oil from Erythrina caffra Thunb. used in treatment of infections and complications associated with gastrointestinal infections in South Africa, 7 (), pp1-1.

OLAJUYIGBEO, . Biological activities and chemical composition of essential oil from Erythrina caffra Thunb. used in treatment of infections and complications associated with gastrointestinal infections in South Africa. 2021, 7 ():1-1.

OLAJUYIGBE,Olufunmiso , . "Biological activities and chemical composition of essential oil from Erythrina caffra Thunb. used in treatment of infections and complications associated with gastrointestinal infections in South Africa", 7 . (2021) : 1-1.

O.Olufunmiso , "Biological activities and chemical composition of essential oil from Erythrina caffra Thunb. used in treatment of infections and complications associated with gastrointestinal infections in South Africa" vol.7, no., pp. 1-1, 2021.

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