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Antibacterial activity of defatted and non-defatted methanolic extracts of Aframomum melegueta K. Schum against multidrug resistant bacteria of clinical importance.

Authors: OLAJUYIGBE Olufunmiso

Publication Type: Journal article

Journal: The Scientific World Journal

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Abstract

Background: The potential of transmitting multidrug resistant Staphylococcus aureus from asymptomatic individuals to healthy individuals could constitute a great challenge to antimicrobial therapy.

Methods: The antibiograms of the S. aureus from asymptomatic individuals were determined by disk diffusion and agar dilution assay techniques with different antibiotics and vancomycin.

Results: Of the 152 S. aureus isolated, (59)38.8% isolates were multi-drug resistant strains. Streptomycin was the most effective and inhibited (135)88.82% of the isolates while ceftazidime inhibited (24)15.8% of the isolates. While (82)54.0% of the isolates inhibited by cefuroxime had resistant colonies within their inhibition zones (Rc) and ofloxacin inhibited (100)65.8% of the isolates without having resistant colonies within the inhibition zones, ceftazidime inhibited (7)4.6% of the isolates with resistant colonies within the inhibition zones. Subjecting the isolates to vancomycin showed that (27)17.8% were resistant to 2 µg/ml, (43)28.3% were resistant to 4 µg/ml and (27)17.8% of the isolates were simultaneously resistant to both concentrations of vancomycin. Although (100)65.8% of the isolates had MARindex ?0.2, (52)34.2% of the isolates had MARindex ? 0.2 and (65)428% of the isolates were considered multidrug resistant strains.

Conclusion: The isolation of multi-drug and vancomycin intermediate resistant strains of S. aureus in high percentage, in this study, presents a great threat to clinicians and general populace. The vancomycin intermediate resistant S. aureus (VISA) in asymptomatic individuals could be a critical concern to the therapeutic dilemma to be added to the presence of multi-drug resistance. A more sustainable therapy must be in place to prevent its dissemination or the outbreak of its infection.

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OLAJUYIGBE,O. . (2020). Antibacterial activity of defatted and non-defatted methanolic extracts of Aframomum melegueta K. Schum against multidrug resistant bacteria of clinical importance., 4808432 (), 1-1.

OLAJUYIGBE,O. . "Antibacterial activity of defatted and non-defatted methanolic extracts of Aframomum melegueta K. Schum against multidrug resistant bacteria of clinical importance." 4808432, no (), (2020): 1-1.

OLAJUYIGBE,O. and . (2020). Antibacterial activity of defatted and non-defatted methanolic extracts of Aframomum melegueta K. Schum against multidrug resistant bacteria of clinical importance., 4808432 (), pp1-1.

OLAJUYIGBEO, . Antibacterial activity of defatted and non-defatted methanolic extracts of Aframomum melegueta K. Schum against multidrug resistant bacteria of clinical importance.. 2020, 4808432 ():1-1.

OLAJUYIGBE,Olufunmiso , . "Antibacterial activity of defatted and non-defatted methanolic extracts of Aframomum melegueta K. Schum against multidrug resistant bacteria of clinical importance.", 4808432 . (2020) : 1-1.

O.Olufunmiso , "Antibacterial activity of defatted and non-defatted methanolic extracts of Aframomum melegueta K. Schum against multidrug resistant bacteria of clinical importance." vol.4808432, no., pp. 1-1, 2020.

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