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Antibacterial Activity of Defatted and Nondefatted Methanolic Extracts of Aframomum melegueta K. Schum. against Multidrug- Resistant Bacteria of Clinical Importance

Authors: OLAJUYIGBE Olufunmiso

Publication Type: Journal article

Journal: The Scientific World Journal

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Abstract

The antibacterial activity of the extracts of Aframomum meleguetaincludingn-hexane extract (NHE), nondefatted methanol extract(NDME), and defatted methanol extract (DME) was investigated in this study. (e NHE exhibited no antibacterial activity. (e DMEshowed higher antibacterial activity than the NDME against the different isolates. At the highest concentration of 10 mg/mL in agardiffusion, NDME produced inhibition zones ranging from 11 to 29 mm against the microorganisms while DME produced inhibitionzones ranging from 20 to 40 mm with the concentration of 10 mg/mL against the microorganisms. 0.1 mg/mL of the DME produced inhibition zones ranging between 12 and 14 mm in Aeromonas hydrophila ATCC 35654 and Pseudomonas aeruginosaATCC 15442, respectively, while none of the isolates were inhibited by the NDME at a concentration of 1 mg/mL or less. In the agar dilution assay, theMICs of the NDME and DME ranged between 0.31 and 10 mg/mL, but more isolates were inhibited at 0.31 mg/mL of DME than thosein NDME. In macrobroth assay, the MICs of the NDME ranged between 0.15 and 5.0 mg/mL and the MBCs ranged between 0.63 and5.0 mg/mL, and the MICs of the DME ranged between 0.08 and 5.0 mg/mL and the MBCs were between 0.31 and 5.0 mg/mL. (is studyindicated that DME was more active with higher antibacterial activity than the NDME of this plant, and extracting the fatty portion ofplant materials prior susceptibility testing would allow plant extracts to be more effective as well as justifying the use of Aframomum meleguetain traditional medicine for the treatment of bacterial infections.

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OLAJUYIGBE,O. . (2020). Antibacterial Activity of Defatted and Nondefatted Methanolic Extracts of Aframomum melegueta K. Schum. against Multidrug- Resistant Bacteria of Clinical Importance, 808432 (), 1-1.

OLAJUYIGBE,O. . "Antibacterial Activity of Defatted and Nondefatted Methanolic Extracts of Aframomum melegueta K. Schum. against Multidrug- Resistant Bacteria of Clinical Importance" 808432, no (), (2020): 1-1.

OLAJUYIGBE,O. and . (2020). Antibacterial Activity of Defatted and Nondefatted Methanolic Extracts of Aframomum melegueta K. Schum. against Multidrug- Resistant Bacteria of Clinical Importance, 808432 (), pp1-1.

OLAJUYIGBEO, . Antibacterial Activity of Defatted and Nondefatted Methanolic Extracts of Aframomum melegueta K. Schum. against Multidrug- Resistant Bacteria of Clinical Importance. 2020, 808432 ():1-1.

OLAJUYIGBE,Olufunmiso , . "Antibacterial Activity of Defatted and Nondefatted Methanolic Extracts of Aframomum melegueta K. Schum. against Multidrug- Resistant Bacteria of Clinical Importance", 808432 . (2020) : 1-1.

O.Olufunmiso , "Antibacterial Activity of Defatted and Nondefatted Methanolic Extracts of Aframomum melegueta K. Schum. against Multidrug- Resistant Bacteria of Clinical Importance" vol.808432, no., pp. 1-1, 2020.

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