Blood-Boosting and Gastro-protective influencesof DietsSupplemented with Ganoderma lucidumonIndomethacin Gastric Ulcer Induced Rats
Authors:
AINA Ayandiran
Publication Type: Journal article
Journal: Scholars Academic Journal Of Biosciences
ISSN Number:
0
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Abstract
Ganoderma lucidum(Gl),collected from Saki, Oyo State, South Western Nigeria, was employed as dietary supplements in the assessments of blood-boosting and gastro-protective actions on male Wistar rats (Rattus norvegicus). The antiulcer, biochemical and haematological influences were carried out in triplicates usingstandard methods. Data were expressed as Mean ± SE, interpreted using ANOVA and test of significance was carried out using DMRT (P? 0.05).Gastric nitric oxide, mucin, sulfhydryl, hydrogen peroxide and H+/K+-ATPase activities were significantly different when compared with ulcerated untreated control (CU).When the same parameters were used in comparison with the normal control (CN), values obtained for haematological and plasma biochemical variables were not significantly different across all G.lucidumtreatment groups. The histopathological analysis of the stomach tissues revealed that there were marked ulcer inhibitions. G.lucidumtreatment group demonstrated blood enhancing and gastro-protective behavior through predominant antioxidant activities. The implications of thesefindings were discussed.