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Addressing the global surge of COVID-19 cases: Insights from diagnostics, improved treatment strategies, vaccine development and application

Authors: Kamoru Adedokun, OLARINMOYE Ayodeji , Lawal Olayemi, Muhammed Shehu, Jelili Mustapha, Ramat Kamorudeen, Sulaimon A. Nassar

Publication Type: Journal article

Journal: Journal Of Clinical And Translational Research

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Abstract

Background and aim: As the rage of coronavirus disease 2019 (COVID-19) pandemic continues to spread globally, much effort is being directed to contain it through various efforts – genomic studies, drug discoveries, clinical trials, vaccine development, and the innovation of diagnostic techniques. However, some pertinent areas involving accurate and sensitive diagnostics, immunoglobulin specificity, evolution of mutant strains of severe acute respiratory syndrome coronavirus 2 (SARSCoV-2), and the drug combination strategy to combat it still require more attention.
Methods: This review critically examines the COVID-19 response and containment operations. It also addresses some standing challenges involving the areas of diagnostics, vaccine development and prospect, and treatment strategies in relation to antiviral drug treatment and immunotherapy. Designated set of keywords such as “SARS-CoV-2;” “coronavirus;” “severe acute respiratory syndrome coronavirus;” “repurposed;” “vaccination;” “containment;” “laboratory diagnostic;” “immunotherapy;” “antiviral;” “antiparasitic;” “antibiotic;” “antiprotozoal;” “antibody;” “antiinflammatory;” “antitumor;” “corticosteroid;” “hypertensive drug;” “statin;” “supplement;” and “biological” along with “COVID-19” were inserted on electronic databases to retrieve articles and clinical trial information relevant to the study objectives. The search databases included ClinicalTrials. gov, NIH.gov, PubMed, Scinapse, CINAHL, Medline, Google Scholar, Academic Search Premier, SAGE, EBSCO Host, and Scopus.
Relevance for patients: The difficulties associated with SARS-CoV-2 rapid mutations are unceasingly
evolving and re-evolving. These pose serious concerns and downplay the efficacy and effectiveness
of the current pipeline antiviral drugs and vaccines. Entities encompassing immunotherapy, antiviral
drug therapies, viral genomics, protein-protein interaction, and improved diagnostics as well as
drug combination strategy against the emerging genetic variability of SARS-CoV-2 were critically
appraised. This study suggests that robust collaborations in the development of more sensitive, rapid
and accurate diagnostics, development of immunoglobulin specific agents and improved anti-viral
treatment focus against multiple mutant genes of SARS-CoV-2 should be aggressively pursued for the
overall benefits of COVID-19 patients.

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Kamoru,A.A OLARINMOYE,A. Lawal,O.O Muhammed,R.S Jelili,O.M Ramat,T.K Sulaimon,A.N . (2021). Addressing the global surge of COVID-19 cases: Insights from diagnostics, improved treatment strategies, vaccine development and application, 7 (), 127-127.

Kamoru,A.A OLARINMOYE,A. Lawal,O.O Muhammed,R.S Jelili,O.M Ramat,T.K Sulaimon,A.N . "Addressing the global surge of COVID-19 cases: Insights from diagnostics, improved treatment strategies, vaccine development and application" 7, no (), (2021): 127-127.

Kamoru,A.A and OLARINMOYE,A. and Lawal,O.O and Muhammed,R.S and Jelili,O.M and Ramat,T.K and Sulaimon,A.N and . (2021). Addressing the global surge of COVID-19 cases: Insights from diagnostics, improved treatment strategies, vaccine development and application, 7 (), pp127-127.

KamoruAA, OLARINMOYEA, LawalOO, MuhammedRS, JeliliOM, RamatTK, SulaimonAN, . Addressing the global surge of COVID-19 cases: Insights from diagnostics, improved treatment strategies, vaccine development and application. 2021, 7 ():127-127.

Kamoru,A. Adedokun, OLARINMOYE,Ayodeji , Lawal,O. Olayemi, Muhammed,R. Shehu, Jelili,O. Mustapha, Ramat,T. Kamorudeen, and Sulaimon,A. Nassar . "Addressing the global surge of COVID-19 cases: Insights from diagnostics, improved treatment strategies, vaccine development and application", 7 . (2021) : 127-127.

K.A. Adedokun O.Ayodeji L.O. Olayemi M.R. Shehu J.O. Mustapha R.T. Kamorudeen & S.A. Nassar , "Addressing the global surge of COVID-19 cases: Insights from diagnostics, improved treatment strategies, vaccine development and application" vol.7, no., pp. 127-127, 2021.

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