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Reno-Hepatoprotective and Antidiabetic Properties of Methanol Leaf Extract of Laportea Aestuans in Wistar Rats

Authors: ADETUNJI Oluwaseyi , Jeremiah Olugbami, Ayodeji Adegoke, Michael Gbadegesin, Oyeronke Adunni Odunola

Publication Type: Journal article

Journal: Journal Of Evidence-based Integrative Medicine

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Abstract

Toxicities due to exposure to arsenic-contaminated water and the occurrence of diabetes mellitus are major health concerns. Treatment of these concerns using therapeutic measures have recorded limited success. Traditionally, Laportea aestuans (LA) has been used in managing various diseases. Hence, we investigated the reno-hepatoprotective/antidiabetic potentials of methanol leaf extract of LA (MeLELA) in male Wistar rats. Thirty ats (100-150 g) were equally distributed into 6 groups: Group I (vehicletreated); group II received 2.5 mg/kg sodium arsenite (SA) thrice a week for 2 weeks; group III received streptozotocin (STZ, 50 mg/kg once); group IV received 200 mg/kg LA daily for 14 days; group V received SA and LA; group VI received STZ and LA. Sodium arsenite and STZ induced reno-hepatotoxicity and diabetes, respectively. Phytochemical screening, biomarkers/enzyme activities, blood glucose levels, micronucleus assay, kidney, liver and pancreas histologies were determined according to standard procedures. Alkaloids, carotenoids and flavonoids were present in abundance. Both SA-and STZ-treated groups recorded significant (p < 0>

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ADETUNJI,O. Jeremiah,O.O Ayodeji,M.A Michael,A.G Oyeronke,A.O . (2021). Reno-Hepatoprotective and Antidiabetic Properties of Methanol Leaf Extract of Laportea Aestuans in Wistar Rats, 26 (), 1-1.

ADETUNJI,O. Jeremiah,O.O Ayodeji,M.A Michael,A.G Oyeronke,A.O . "Reno-Hepatoprotective and Antidiabetic Properties of Methanol Leaf Extract of Laportea Aestuans in Wistar Rats" 26, no (), (2021): 1-1.

ADETUNJI,O. and Jeremiah,O.O and Ayodeji,M.A and Michael,A.G and Oyeronke,A.O and . (2021). Reno-Hepatoprotective and Antidiabetic Properties of Methanol Leaf Extract of Laportea Aestuans in Wistar Rats, 26 (), pp1-1.

ADETUNJIO, JeremiahOO, AyodejiMA, MichaelAG, OyeronkeAO, . Reno-Hepatoprotective and Antidiabetic Properties of Methanol Leaf Extract of Laportea Aestuans in Wistar Rats. 2021, 26 ():1-1.

ADETUNJI,Oluwaseyi , Jeremiah,Olorunjuwon Olugbami, Ayodeji,Mathias Adegoke, Michael,Adedapo Gbadegesin, and Oyeronke,Adunni Odunola . "Reno-Hepatoprotective and Antidiabetic Properties of Methanol Leaf Extract of Laportea Aestuans in Wistar Rats", 26 . (2021) : 1-1.

A.Oluwaseyi J.Olorunjuwon Olugbami A.Mathias Adegoke M.Adedapo Gbadegesin & O.Adunni Odunola , "Reno-Hepatoprotective and Antidiabetic Properties of Methanol Leaf Extract of Laportea Aestuans in Wistar Rats" vol.26, no., pp. 1-1, 2021.

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