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In vitro antioxidant and anti-inflammatory activities of methanol extract of Vitellaria paradoxa seed (shea seed)

Authors: OGUNBIYI Babafemi , ADETUNJI Oluwaseyi , Ogunyemi Olubunmi , AMAH Gogonte , ADETAYO Modupe , & OLAJIDE Laide

Publication Type: Journal article

Journal: World Journal Of Advanced Research And Reviews

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Abstract

Vitellaria paraodoxa (shea tree) is the source of shea seed from which the well-known shea butter is derived. The methanol extract of shea seed was evaluated for its anti-inflammatory and antioxidant activities using diclofenac sodium and ascorbic acid as standard respectively in in vitro methods. The anti-inflammatory activity was determined by inhibition of protein denaturation of bovine serum albumin (BSA) and erythrocyte membrane stabilization of human red blood cell. The antioxidant activity was evaluated using 1, 1-diphenyl-2-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP), thiobarbituric acid reactive substances (TBARS) and total antioxidant capacity (TAC) assays. The results showed that methanol extract of V. paradoxa seed at different concentration protects the heat induced protein denaturation with the maximum percentage inhibition of 27% (IC50=303.0 µg/mL, p<0 IC50=261.4 IC50=31.47 IC50=33.89 IC50=8.95 IC50=6.72 IC50=51.79 IC50=52.30>V. paradoxa seed may possess strong anti-inflammatory and antioxidant activities which could constitute a potential source for development of new therapy.

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OGUNBIYI,B. ADETUNJI,O. Ogunyemi,O. AMAH,G. ADETAYO,M. OLAJIDE,L. . (2021). In vitro antioxidant and anti-inflammatory activities of methanol extract of Vitellaria paradoxa seed (shea seed), 11 (), 57-57.

OGUNBIYI,B. ADETUNJI,O. Ogunyemi,O. AMAH,G. ADETAYO,M. OLAJIDE,L. . "In vitro antioxidant and anti-inflammatory activities of methanol extract of Vitellaria paradoxa seed (shea seed)" 11, no (), (2021): 57-57.

OGUNBIYI,B. and ADETUNJI,O. and Ogunyemi,O. and AMAH,G. and ADETAYO,M. and OLAJIDE,L. and . (2021). In vitro antioxidant and anti-inflammatory activities of methanol extract of Vitellaria paradoxa seed (shea seed), 11 (), pp57-57.

OGUNBIYIB, ADETUNJIO, OgunyemiO, AMAHG, ADETAYOM, OLAJIDEL, . In vitro antioxidant and anti-inflammatory activities of methanol extract of Vitellaria paradoxa seed (shea seed). 2021, 11 ():57-57.

OGUNBIYI,Babafemi , ADETUNJI,Oluwaseyi , Ogunyemi,Olubunmi , AMAH,Gogonte , ADETAYO,Modupe , and OLAJIDE,Laide . "In vitro antioxidant and anti-inflammatory activities of methanol extract of Vitellaria paradoxa seed (shea seed)", 11 . (2021) : 57-57.

O.Babafemi A.Oluwaseyi O.Olubunmi A.Gogonte A.Modupe & O.Laide , "In vitro antioxidant and anti-inflammatory activities of methanol extract of Vitellaria paradoxa seed (shea seed)" vol.11, no., pp. 57-57, 2021.

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