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In vitro ethnotherapeutic potential assessment of the acetone extract of Ziziphus mucronata Willd. s

Authors: OLAJUYIGBE Olufunmiso

Publication Type: Journal article

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Abstract

The antimicrobial and the cytotoxicity activities of the crude acetone bark extract of Ziziphus mucronata were determined by agar diffusion, macrobroth dilution assays and brine shrimp lethality assay, respectively, to ascertain its relevance in ethnomedicine. The results show that both Gram negative and Gram positive bacteria tested were equally inhibited. At the highest concentration (10000 Âµg/ml) of the extract, the bacterial inhibition zones ranged between 16 and 21 Â± 1.0 mm, the fungal inhibition zones ranged between 13 and 19 Â± 1.0 mm while Fusarium sporotrichioides, Candida glabrata and Trichophyton mucoides were not affected. The minimum inhibitory concentrations (MICs) values of the extract were between 78.1 and 312.5 Âµg/ml for the bacteria while the minimum bactericidal concentrations (MBCs) were between 156.3 and 2500 Âµg/ml. For the fungi, the MICs were between 1250 and 10000 Âµg/ml, the minimum fungicidal concentrations (MFCs) were between 5000 and 20000 Âµg/ml and the LC50 of the brine shrimp lethality assay was 90.27 Âµg/ml indicating a low level of toxicity. The degree of the pharmacological activity of Z. mucronata shows the significant medicinal potential of this plant in the treatment of microbial infections and justifies its use in complementary and alternative medicines in South Africa.

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OLAJUYIGBE,O. . (0000). In vitro ethnotherapeutic potential assessment of the acetone extract of Ziziphus mucronata Willd. s, 0 (), 0-0.

OLAJUYIGBE,O. . "In vitro ethnotherapeutic potential assessment of the acetone extract of Ziziphus mucronata Willd. s" 0, no (), (0000): 0-0.

OLAJUYIGBE,O. and . (0000). In vitro ethnotherapeutic potential assessment of the acetone extract of Ziziphus mucronata Willd. s, 0 (), pp0-0.

OLAJUYIGBEO, . In vitro ethnotherapeutic potential assessment of the acetone extract of Ziziphus mucronata Willd. s. 0000, 0 ():0-0.

OLAJUYIGBE,Olufunmiso , . "In vitro ethnotherapeutic potential assessment of the acetone extract of Ziziphus mucronata Willd. s", 0 . (0000) : 0-0.

O.Olufunmiso , "In vitro ethnotherapeutic potential assessment of the acetone extract of Ziziphus mucronata Willd. s" vol.0, no., pp. 0-0, 0000.

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