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Separation of Ceftibuten Stereo Isomers with 100% Aqueous Mobile Phase Using Zorbax SB-Aq

Authors: ONIGBINDE ADEBAYO

Publication Type: Journal article

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Abstract

Ceftibuten dihydrate is currently one of the safest antimicrobial agents available to clinicians. As a result, it is one of the most frequently prescribed antibiotics. Ceftibuten belongs to the third generation of cephalosporin antibiotics (cephems), which are used to treat many varieties of infections caused by gram-positive and negative bacteria. Ceftibuten has two stereo isomers, the (Z) and the (E) isomers. Most HPLC solvents are considered hazardous to health and to the environment. Safe usage and disposal of large volumes of such solvents has always posed problems. Availability of columns, such as Zorbax SB-Aq, that can be used under high aqueous conditions and still retain consistent retention, resolution, selectivity, and peak shape is a great step in reducing the environmental impact of these solvents. Attempts to separate ceftibuten isomers on C18 columns with low percentages of organic modifiers (2%) did not give good resolution and peak shape (Figure 1). However, separation of ceftibuten isomers was achieved with 100% aqueous mobile phases on Zorbax SB-Aq column (Figure 2). Ceftibuten also exhibited very good linearity and a low limit of detection (LOD) (Figure 3).

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ONIGBINDE,A. . (0000). Separation of Ceftibuten Stereo Isomers with 100% Aqueous Mobile Phase Using Zorbax SB-Aq , 0 (), 0-0.

ONIGBINDE,A. . "Separation of Ceftibuten Stereo Isomers with 100% Aqueous Mobile Phase Using Zorbax SB-Aq " 0, no (), (0000): 0-0.

ONIGBINDE,A. and . (0000). Separation of Ceftibuten Stereo Isomers with 100% Aqueous Mobile Phase Using Zorbax SB-Aq , 0 (), pp0-0.

ONIGBINDEA, . Separation of Ceftibuten Stereo Isomers with 100% Aqueous Mobile Phase Using Zorbax SB-Aq . 0000, 0 ():0-0.

ONIGBINDE,ADEBAYO , . "Separation of Ceftibuten Stereo Isomers with 100% Aqueous Mobile Phase Using Zorbax SB-Aq ", 0 . (0000) : 0-0.

O.ADEBAYO , "Separation of Ceftibuten Stereo Isomers with 100% Aqueous Mobile Phase Using Zorbax SB-Aq " vol.0, no., pp. 0-0, 0000.

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