Abstract
condition.
Objective: This research investigated the effect of white cabbage aqueous extract on the serum insulin, insulin
resistance and oxidative stress in pre-diabetes induced male albino rats.
Methods: Prepared extracts from fresh and dried cabbage and thirty male albino rats grouped into six were used
for the study. The positive control was fed regular diet, while negative control was fed high sucrose feed and the
four test groups were fed high sucrose feed and extract. Different test group received 50 or 100 mg/kg of either
of the extracts. The fasting blood sugar at baseline and at two weeks’ interval was recorded. At the end of the
experiment at six weeks, the serum insulin, oral glucose tolerance test and liver oxidative stress were determined.
Results were analyzed using Analysis of Variance (p < 0>
glucose and Graph pad prism 5.
Results: The extracts controlled the serum insulin and cell-resistance to insulin of the rats. There was a reduction
in the malondialdehyde (MDA) and significant reduction in the activities ofsuperoxide dismutase (SOD) and
catalase (CAT) by the extract while glutathione (GSH) increased. The MDA, SOD, CAT and GSH for the negative
control group being 0.85 mg/ml, 0.8 mg/ml, 19.53 mg/ml and 5.18 µmol/ml while the highest for the test groups
was; 0.84 mg/ml, 0.74 mg/ml, 17.37 mg/ml and 5.85 µmol/ml.
Conclusion: Cabbage had potential of reducing liver oxidative stress in pre-diabetic condition.
